| Testosterone induces redistribution of forkhead box-3a and down-regulation of growth and differentiation factor 9 messenger ribonucleic acid expression at early stage of mouse folliculogenesis. | |
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MedLine Citation:
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PMID: 20032061 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Increasing evidence has shown that excess androgen may be a main cause of polycystic ovary syndrome (PCOS). However, the molecular mechanism of androgen action on the ovary is unclear. To investigate the possible impacts of androgen on early follicular development, neonatal mouse ovaries mainly containing primordial follicles were cultured with testosterone. We demonstrated that the number of primary follicles was increased after 10 d culture with testosterone treatment via phosphatidylinositol 3-kinase/Akt pathway. Androgen induced Forkhead box (Foxo)-3a activation, and translocation of Foxo3a protein from oocyte nuclei to cytoplasm, which might be a key step for primordial follicle activation. Interestingly, testosterone was also capable of down-regulating growth and differentiation factor-9 expression via its receptor. In summary, we infer that intraovarian excess androgen in PCOS might result in excess early follicles by inducing oocyte Foxo3a translocation and follicular arrest by down-regulating growth and differentiation factor-9 expression. |
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Authors:
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Jun-Ling Yang; Chun-Ping Zhang; Lei Li; Lin Huang; Shao-Yang Ji; Cui-Ling Lu; Cui-Hong Fan; Huan Cai; Yu Ren; Zhao-Yuan Hu; Fei Gao; Yi-Xun Liu |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-12-23 |
Journal Detail:
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Title: Endocrinology Volume: 151 ISSN: 1945-7170 ISO Abbreviation: Endocrinology Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-26 Completed Date: 2010-02-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375040 Medline TA: Endocrinology Country: United States |
Other Details:
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Languages: eng Pagination: 774-82 Citation Subset: AIM; IM |
Affiliation:
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State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Androgens
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physiology Animals Animals, Newborn DNA Primers Down-Regulation / drug effects Female Gene Expression Regulation / drug effects Genes, Reporter Growth Differentiation Factor 9 / genetics* Hepatocyte Nuclear Factor 3-gamma / physiology* Male Mice Ovarian Follicle / cytology, physiology Ovary / cytology, pathology, physiology*, physiopathology Phosphorylation Plasmids Polycystic Ovary Syndrome / physiopathology Polymerase Chain Reaction Proto-Oncogene Proteins c-akt / metabolism RNA, Messenger / genetics Testis / physiology Testosterone / pharmacology*, physiology |
| Chemical | |
Reg. No./Substance:
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0/Androgens; 0/DNA Primers; 0/Foxa3 protein, mouse; 0/Gdf9 protein, mouse; 0/Growth Differentiation Factor 9; 0/RNA, Messenger; 135845-91-9/Hepatocyte Nuclear Factor 3-gamma; 58-22-0/Testosterone; EC 2.7.11.1/Proto-Oncogene Proteins c-akt |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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