| Testosterone and the Child (0-12years) with Klinefelter Syndrome (47XXY): A Review. | |
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MedLine Citation:
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PMID: 21284716 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Aim: To review the evidence base for providing testosterone therapy in the infant and prepubertal child with Klinefelter syndrome(KS). Methods: Major databases were searched to identify articles that addressed the role of testosterone in the development of the male fetus with and without Klinefelter syndrome, and that characterized testicular function in infants with Klinefelter syndrome. Results: Infants with Klinefelter syndrome have been shown to have an increased frequency of clinical features consistent with deficient testosterone production. However, there are conflicting results regarding whether testosterone levels are low or normal. No direct data address the outcome of therapy in the prepubertal child. Conclusion: There is an absence of data that directly address the risks and benefits of testosterone therapy in prepubertal children with Klinefelter syndrome outside of the entity of microphallus. At this time there is no other documented benefit for testosterone therapy in these children. |
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Authors:
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Ilene Fennoy |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-1 |
Journal Detail:
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Title: Acta paediatrica (Oslo, Norway : 1992) Volume: - ISSN: 1651-2227 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Foundation Acta Paediatrica. |
Affiliation:
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Department of Pediatrics, Columbia University Medical Center, New York, NY. |
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