Document Detail

Testis and epididymis of the Indian wall lizard (Hemidactylus flaviviridis): effects of flutamide on FSH and testosterone influenced spermatogenesis, Leydig cell, and epididymis.
MedLine Citation:
PMID:  1960735     Owner:  NLM     Status:  MEDLINE    
To determine the separate spermatogenic actions of FSH and testosterone, adult male lizards Hemidactylus flaviviridis with recrudescent testes were administered the non-steroidal antiandrogen flutamide either alone or in combination with FSH or testosterone, and the histology and histochemistry of the testes and ductus epididymides were studied. Flutamide-treated animals displayed a marked hypertrophy of Leydig cells. A few spermatids were also seen in testis of more than half the animals treated with flutamide. Flutamide also produced a significant increase of primary spermatocytes; no spermatids were observed in controls. A significant inhibition of spermatogenesis was noted in lizards treated either with testosterone alone or in combination with flutamide. Ovine FSH treatment caused a significant stimulation of spermatogenesis, as indicated by the increase of primary and secondary spermatocytes and the transformation of secondary spermatocytes into spermatids or, in a few cases, into spermatozoa. A considerable depletion of sudanophilic lipid and moderate delta 5-3 beta-hydroxysteroid dehydrogenase activity was noted in the Leydig cells of FSH-treated animals indicating enhanced steroidogenesis. Similar results were obtained when lizards were treated with flutamide + FSH. The effects of simultaneous treatment of flutamide with FSH or testosterone on ductus epididymidis revealed that flutamide markedly inhibited the epithelial cell height and lumen diameter with a loss of luminal content when compared to FSH or testosterone-treated lizards.
U Rai; S Haider
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of morphology     Volume:  209     ISSN:  0362-2525     ISO Abbreviation:  J. Morphol.     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1992-01-06     Completed Date:  1992-01-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0406125     Medline TA:  J Morphol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  133-42     Citation Subset:  IM    
Centre of Advanced Study in Zoology, Banaras Hindu University, Varanasi, India.
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MeSH Terms
Epididymis / anatomy & histology,  drug effects
Flutamide / pharmacology*
Follicle Stimulating Hormone / physiology*
Leydig Cells / drug effects
Lizards / anatomy & histology*,  physiology*
Spermatogenesis / drug effects
Testosterone / physiology*
Reg. No./Substance:
13311-84-7/Flutamide; 58-22-0/Testosterone; 9002-68-0/Follicle Stimulating Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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