Document Detail


Testing surfactant treatment responses: a comparison of two models.
MedLine Citation:
PMID:  9096897     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have compared treatment responses of two surfactants in two animal models of respiratory distress syndrome. Preterm rabbits at 27 days gestation and premature lambs at 126 days gestation were treated with natural sheep surfactant Survanta (Ross Laboratories), or no surfactant and then were ventilated with the same ventilation style to achieve tidal volumes of 8 ml/kg. Dynamic compliances at 15 min were higher for control and surfactant-treated rabbits than for preterm lambs. Sheep surfactant and Survanta increased compliances in rabbits, but only sheep-surfactant-treated lambs had compliances higher than controls at 15 min of age. Maximal lung volumes (milliliters per kilogram) of the rabbits (after 15 min ventilation) were about twice those of the lambs (after 4 h of ventilation). Lung volumes of sheep-surfactant-treated rabbits were larger than for Survanta-treated rabbits, but no differences in lung volume were evident between the surfactant-treated lambs. The two models for testing surfactants do not give the same results when directly compared.
Authors:
M D Henry; M Ikegami; A H Jobe
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biology of the neonate     Volume:  71     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1997  
Date Detail:
Created Date:  1997-06-09     Completed Date:  1997-06-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  181-9     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Harbor-UCLA Medical Center, UCLA School of Medicine, Torrance 90502, USA.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Biological Products*
Female
Humans
Infant, Newborn
Infant, Premature
Lung Compliance / drug effects*
Pregnancy
Pulmonary Surfactants / pharmacology*
Rabbits
Reproducibility of Results
Respiratory Distress Syndrome, Newborn / drug therapy*,  physiopathology
Serum Albumin / pharmacokinetics
Sheep
Tidal Volume / drug effects
Grant Support
ID/Acronym/Agency:
HD-11932/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Biological Products; 0/Pulmonary Surfactants; 0/Serum Albumin; 108778-82-1/beractant

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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