Document Detail


Testing sensitivity of Neisseria gonorrhoeae to spectinomycin.
MedLine Citation:
PMID:  3160647     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A concentration of 16 mg/l spectinomycin incorporated in agar gave the best discrimination between Neisseria gonorrhoeae sensitive and resistant to spectinomycin. This method was compared with spectinomycin sensitivity testing with 25 micrograms or 100 micrograms discs. Both methods agreed fully for 197 spectinomycin sensitive and three spectinomycin resistant gonococci. The agar incorporation "breakpoint" concentration technique failed to detect a small spectinomycin resistant population in a fourth isolate, which was detected by disc testing. It may be possible to predict the emergence of spectinomycin resistance among strains of N gonorrhoeae.
Authors:
J M Hilton; C A Ison; C S Easmon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Genitourinary medicine     Volume:  61     ISSN:  0266-4348     ISO Abbreviation:  Genitourin Med     Publication Date:  1985 Aug 
Date Detail:
Created Date:  1985-09-06     Completed Date:  1985-09-06     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  8503853     Medline TA:  Genitourin Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  241-3     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Microbial Sensitivity Tests
Neisseria gonorrhoeae / drug effects*,  enzymology
Penicillinase / biosynthesis
Spectinomycin / pharmacology*
Chemical
Reg. No./Substance:
1695-77-8/Spectinomycin; EC 3.5.2.-/Penicillinase
Comments/Corrections

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