Document Detail

Testing for hematologic disorders and complications.
MedLine Citation:
PMID:  12848447     Owner:  NLM     Status:  MEDLINE    
This review summarizes state-of-the-art and emerging techniques in the antenatal diagnosis of fetal anemia and hemoglobinopathies. Fetal anemia may result from hemolytic disease, hemorrhage, suppression of erythropoiesis, infection (eg, parvovirus B19), or trauma. The clinical laboratory plays an essential role in the evaluation of these disorders by way of the use of various hematologic, biochemical, serologic, cytometric, and molecular genetics methods. Hemoglobinopathies are the most common class of single gene disorders worldwide. The authors have used the example of homozygous alpha-thalassemia major (Hb Barts disease) as a paradigmatic case for antenatal hemoglobinopathy screening. Perhaps the most familiar indication for hematologic screening in pregnancy is HDFN, most commonly in pregnancies previously sensitized to the RhD antigen. All pregnant women, regardless of their past medical or obstetric history or previous antibody screens, should have ABO/Rh blood typing and a red cell antibody screen performed at the first prenatal visit. Long-established methods for assaying FMH (KB method), microcytosis (hemogram with red cell indices), and blood group incompatibility (direct antigen test, serologies) remain critical for rapid, sensitive diagnosis. Analysis of fetal free DNA in maternal plasma holds the promise for rapid, ultrasensitive, and noninvasive detection of many fetal hematologic disorders.
Lewis P Rubin; Katrine Hansen
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinics in laboratory medicine     Volume:  23     ISSN:  0272-2712     ISO Abbreviation:  Clin. Lab. Med.     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-07-09     Completed Date:  2004-01-06     Revised Date:  2006-03-28    
Medline Journal Info:
Nlm Unique ID:  8100174     Medline TA:  Clin Lab Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  317-43     Citation Subset:  IM    
Department of Pediatrics, Program in Fetal Medicine, Brown Medical School and Women and Infants Hospital of Rhode Island, 101 Dudley Street, Providence, RI 02905-2499, USA.
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MeSH Terms
Fetal Blood
Fetal Diseases / blood,  diagnosis*
Hematologic Diseases / complications,  congenital,  diagnosis*
Prenatal Diagnosis*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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