Document Detail


Testing for food reactions: the good, the bad, and the ugly.
MedLine Citation:
PMID:  20413700     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An increasing number of commercial tests for food allergies are marketed to consumers and healthcare practitioners with tenuous claims. The aim of this article is to provide an evidence-based review of the tests and procedures that currently are used for patients with suspected food allergy. A systematic review of the literature evaluating the validity of tests and procedures used in food reactions was performed using conventional search engines (eg, PubMed, Ovid) as well as consumer sites (eg, Google, Bing). The National Library of Medicine Medical Subject Headings (MeSH) term food hypersensitivity was used along with food allergy testing, food sensitivity testing, food intolerance testing, and adverse food reactions. Of the results obtained, testing for immunoglobulin E (IgE)-mediated food allergy was best represented in PubMed. IgE-based testing continues to be the gold standard for suspected food allergies. Among modalities used by many conventional and alternative practitioners, immunoglobulin G (IgG)-based testing showed promise, with clinically meaningful results. It has been proven useful as a guide for elimination diets, with clinical impact for a variety of diseases. Mediator release testing and antigen leukocyte cellular antibody testing were only represented on consumer sites. Further investigation into the validity and the clinical application of these tests and procedures is required. Disclosing the basis for food reactions continues to present a diagnostic challenge, and testing for food allergies in the context of an appropriate clinical history is paramount to making the correct diagnosis.
Authors:
Gerard E Mullin; Kathie M Swift; Liz Lipski; Laura K Turnbull; S Devi Rampertab
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition     Volume:  25     ISSN:  1941-2452     ISO Abbreviation:  Nutr Clin Pract     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-23     Completed Date:  2010-07-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8606733     Medline TA:  Nutr Clin Pract     Country:  United States    
Other Details:
Languages:  eng     Pagination:  192-8     Citation Subset:  IM; N    
Affiliation:
Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. gmullin1@jhmi.edu
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MeSH Terms
Descriptor/Qualifier:
Evidence-Based Medicine
Food Hypersensitivity / blood,  diagnosis*,  immunology
Humans
Immunoglobulin E / blood,  immunology*
Immunoglobulin G / blood,  immunology*
Skin Tests*
Chemical
Reg. No./Substance:
0/Immunoglobulin G; 37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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