| Testing covariates of Type 2 diabetes-cognition associations in older adults: moderating or mediating effects? | |
| | |
MedLine Citation:
|
PMID: 20804243 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: The general goal of this study was to advance our understanding of Type 2 diabetes (T2D)-cognition relationships in older adults by linking and testing comprehensive sets of potential moderators, potential mediators, and multiple cognitive outcomes. METHOD: We identified in the literature 13 health-related (but T2D-distal) potential covariates, representing four informal domains (i.e., biological vitality, personal affect, subjective health, lifestyle activities). Cross-sectional data from the Victoria Longitudinal Study (age range = 53-90 years; n = 41 T2D and n = 458 control participants) were used. We first examined whether any of the 13 potential covariates influenced T2D-cognition associations, as measured by a comprehensive neuropsychological battery (15 measures). Next, using standard regression-based moderator and mediator analyses, we systematically tested whether the identified covariates would significantly alter observed T2D-cognition relationships. RESULTS: Six potential covariates were found to be sensitive to T2D associations with performance on seven cognitive measures. Three factors (systolic blood pressure, gait-balance composite, subjective health) were significant mediators. Each mediated multiple cognitive outcomes, especially measures of neurocognitive speed, executive functioning, and episodic memory. CONCLUSIONS: Our findings offer a relatively comprehensive perspective of T2D-related cognitive deficits, comorbidities, and modulating influences. The implications for future research reach across several fields of study and application. These include (1) neuropsychological research on neural and biological bases of T2D-related cognitive decline, (2) clinical research on intervention and treatment strategies, and (3) larger-scale longitudinal studies examining the potential multilateral and dynamic relationships among T2D status, related comorbidities, and cognitive outcomes. |
| | |
Authors:
|
G Peggy McFall; Bonnie P Geall; Ashley L Fischer; Sanda Dolcos; Roger A Dixon |
Related Documents
:
|
22582883 - Partially overlapping mechanisms of language and task control in young and older biling... 2809113 - The robustness of the terminal decline phenomenon: longitudinal data from the digit-spa... 20643153 - Neurological soft signs feature a double dissociation within the language system in wil... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Neuropsychology Volume: 24 ISSN: 1931-1559 ISO Abbreviation: Neuropsychology Publication Date: 2010 Sep |
Date Detail:
|
Created Date: 2010-08-31 Completed Date: 2011-01-04 Revised Date: 2011-09-13 |
Medline Journal Info:
|
Nlm Unique ID: 8904467 Medline TA: Neuropsychology Country: United States |
Other Details:
|
Languages: eng Pagination: 547-62 Citation Subset: IM |
Copyright Information:
|
Copyright 2010 APA, all rights reserved. |
Affiliation:
|
Department of Psychology, University of Alberta, Edmonton, Alberta T6G 2E9, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Activities of Daily Living Aged Aged, 80 and over Aging / physiology, psychology* Case-Control Studies Cognition / physiology Cognition Disorders / complications*, psychology Cross-Sectional Studies Diabetes Complications / psychology* Diabetes Mellitus / physiopathology, psychology* Female Health Status Humans Life Style Male Middle Aged Neuropsychological Tests Quality of Life Reference Values Self Concept Self-Assessment |
| Grant Support | |
ID/Acronym/Agency:
|
R37 AG008235/AG/NIA NIH HHS; R37 AG008235-19/AG/NIA NIH HHS; R37 AG008235-21/AG/NIA NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The road to forgiveness: a meta-analytic synthesis of its situational and dispositional correlates.
Next Document: Influence of age on practice effects in longitudinal neurocognitive change.