| Testing biomechanical strength of in vitro cerebrospinal fluid leak repairs. | |
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MedLine Citation:
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PMID: 19344619 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Repair of cerebrospinal fluid (CSF) leaks with grafts can be augmented with various adjuncts to improve approximation such as tissue adhesives and sutures. Here we test various adjuncts in an in vitro model of CSF leak repairs. METHODS: A novel pressure testing system was designed to evaluate the burst pressures of in vitro CSF leak repairs. Porcine pericranium grafts were harvested and used to repair a 0.5 X 0.5 cm dural defect. These grafts were sealed in place with no adjunct (control), Tisseel fibrin glue (Baxter, Mississauga, ON), suture, U-CLIPs (a self-closing suture substitute; Medtronic, Toronto, ON), or combined suture and Tisseel. Tisseel samples were tested both as underlay and overlay repairs. Samples were incubated overnight in serum and subjected to burst pressure testing, and pressure-time graphs were recorded. Experiments were conducted five times. RESULTS: Mean burst pressures (measured in pounds per square inch) for grafts sealed in place with Tisseel were significantly higher than all other adjuncts (14.9 Tisseel vs 3.9 control vs 4.1 U-CLIP vs 6.2 suture psi; p < .05). U-CLIPs and sutures did not increase burst strength over controls, and sutures did not have a synergistic effect with Tisseel (12.1 psi). Grafts tested with Tisseel were stronger when tested as underlay than as overlay (14.9 vs 3.0 psi). Three patterns of graft failure were observed based on unique pressure-time graphs. CONCLUSIONS: In vitro burst pressure testing demonstrates that Tisseel improves the strength of CSF leak repairs. |
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Authors:
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John R de Almeida; Alan Morris; Cari M Whyne; Adrian L James; Ian J Witterick |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale Volume: 38 ISSN: 1916-0216 ISO Abbreviation: J Otolaryngol Head Neck Surg Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-04-06 Completed Date: 2009-08-14 Revised Date: 2013-04-10 |
Medline Journal Info:
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Nlm Unique ID: 101479544 Medline TA: J Otolaryngol Head Neck Surg Country: Canada |
Other Details:
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Languages: eng Pagination: 106-11 Citation Subset: IM |
Affiliation:
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Department of Otolaryngology, Head and Neck Surgery, Mount Sinai Hospital, The Hospital for Sick Children, Toronto, ON, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biomechanics / physiology* Cerebrospinal Fluid Rhinorrhea / metabolism* Dura Mater / metabolism* Fibrin Tissue Adhesive / therapeutic use* Fibrinogen / metabolism* Skull / metabolism* Swine |
| Chemical | |
Reg. No./Substance:
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0/Fibrin Tissue Adhesive; 9001-32-5/Fibrinogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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