Document Detail


Testing of 2,4,5-T-amino acid conjugates for mutagenic activity in Salmonella typhimurium strains.
MedLine Citation:
PMID:  6377058     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Since amino acid conjugates are plant metabolites of the herbicide 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), 5 amino acid conjugates (aspartic acid, glutamic acid, leucine, methionine and tryptophan) of 2,4,5-T were tested for possible mutagenic activity utilizing 5 strains of Salmonella typhimurium (TA97, TA98, TA100, TA1535 and TA1538) with and without rat-liver microsomal and cytosolic enzymes. These compounds did not cause any significant increase in reversions when compared with controls in the presence or absence of the activating system. Further, linear regression analysis showed no significant (p less than 0.05) dose-response relationships. Thus, it was concluded that the tested amino acid conjugates of 2,4,5-T are not mutagens or promutagens in these assays.
Authors:
K A Rashid; J G Babish; R O Mumma
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Mutation research     Volume:  136     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  1984 Jun 
Date Detail:
Created Date:  1984-08-07     Completed Date:  1984-08-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  217-21     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
2,4,5-Trichlorophenoxyacetic Acid / analogs & derivatives*,  toxicity
Amino Acids / toxicity*
Animals
Biotransformation
Cytosol / metabolism
Liver / metabolism
Microsomes, Liver / metabolism
Mutagenicity Tests
Mutagens / toxicity*
Mutation*
Rats
Salmonella typhimurium / drug effects
Species Specificity
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Mutagens; 93-76-5/2,4,5-Trichlorophenoxyacetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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