Document Detail

Testicular versus epididymal spermatozoa in intracytoplasmic sperm injection treatment cycles.
MedLine Citation:
PMID:  22455287     Owner:  NLM     Status:  In-Process    
BACKGROUND: Normal fertilization and ongoing pregnancy can be achieved using intracytoplasmic sperm injection (ICSI), even with severely immature spermatozoa. However, the published literature documents conflicting results as to the outcome of ICSI.
METHODS: Surgical extraction of spermatozoa in 111 ICSI treatment cycles performed over five years at the Assisted Conception Unit (ACU), University College Hospital (UCH), was retrospectively evaluated to compare the outcome of ICSI treatment using either testicular or epididymal spermatozoa.
RESULTS: A higher normal fertilization rate and lower abnormal fertilization rate was observed in the epididymal spermatozoa group than in the testicular spermatozoa group. Embryo development on day 3 after fertilization and implantation was significantly better in the epididymal spermatozoa group. Clinical and ongoing pregnancy rates were higher and the spontaneous miscarriage rate lower in the epididymal spermatozoa group, but only the clinical pregnancy rate reached statistical significance.
CONCLUSIONS: The origin of surgically extracted spermatozoa has an effect on the success of assisted reproduction using ICSI, and the immaturity of testicular spermatozoa may affect fertilization, embryo development, implantation and pregnancy.
N Hameed; O Ozturk
Related Documents :
25478417 - A rare case of acute lymphoblastic leukaemia in pregnancy- unique maternal-fetal challe...
25300267 - Placental fatty acid transfer: a key factor in fetal growth.
25195877 - Fetal cephalocele: first-trimester sonographic spectrum in a review of 35 cases.
25146367 - A prospective study of screening for hypertensive disorders of pregnancy at 11 to 13 we...
2502487 - Chemotherapy in a pregnant rat model. 1. mitomycin-c: pregnancy-specific kinetics and p...
1451717 - The disposition of valproate and its metabolites in the late first trimester and early ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of Ayub Medical College, Abbottabad : JAMC     Volume:  22     ISSN:  1025-9589     ISO Abbreviation:  J Ayub Med Coll Abbottabad     Publication Date:    2010 Oct-Dec
Date Detail:
Created Date:  2012-03-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8910750     Medline TA:  J Ayub Med Coll Abbottabad     Country:  Pakistan    
Other Details:
Languages:  eng     Pagination:  159-63     Citation Subset:  IM    
PAF Hospital, Munir Road, Lahore, Pakistan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Cardiac arrhythmias and left ventricular hypertrophy in systemic hypertension.
Next Document:  Response to standard interferon A2b and ribavirin combination therapy in chronic hepatitis C treatme...