| Testicular vascular permeability: effects of experimental lesions associated with impaired testis function. | |
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MedLine Citation:
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PMID: 8583568 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Pathologies like varicocele and testicular torsion are known to alter testicular blood flow, either acutely or chronically. The present study was undertaken to determine whether or not alterations in testicular vascular permeability accompany these changes in testicular blood flow. MATERIALS AND METHODS: Testicular vascular permeability was examined by determining the appearance of radiolabelled molecules (m.w. = 18 to 70,000) in testicular interstitial fluid after acute infusion into the proximal testicular artery of the rat. These vascular permeability studies were carried out in control animals, in those with 30 day experimental left varicocele (ELV), or in those having experienced a 1 hour, 720 degrees experimental torsion either 1 hour or 24 hours prior to the study. RESULTS: Experimental left varicocele did not alter vascular permeability to the molecules studied, but 1 hour torsion did cause a significant increase in vascular permeability within 24 hours after repair of the torsion. CONCLUSION: Alteration in vascular permeability is one of the family of events contributing to cell death after repair of experimental testicular torsion, but is not a factor in the pathobiology of experimental varicocele. |
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Authors:
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T T Turner; L A Caplis; C P Rhoades |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of urology Volume: 155 ISSN: 0022-5347 ISO Abbreviation: J. Urol. Publication Date: 1996 Mar |
Date Detail:
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Created Date: 1996-03-19 Completed Date: 1996-03-19 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0376374 Medline TA: J Urol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1078-82 Citation Subset: AIM; IM |
Affiliation:
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Department of Urology, University of Virginia School of Medicine, Charlottesville, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Capillary Permeability* Dextrans / pharmacokinetics Extracellular Space Male Polyethylene Glycols / pharmacokinetics Rats Rats, Sprague-Dawley Spermatic Cord Torsion / physiopathology* Time Factors Tritium / pharmacokinetics Urea / pharmacokinetics Varicocele / physiopathology* |
| Grant Support | |
ID/Acronym/Agency:
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DK 45179/DK/NIDDK NIH HHS; HD 18252/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Polyethylene Glycols; 10028-17-8/Tritium; 57-13-6/Urea; 9004-54-0/Dextrans |
| Comments/Corrections | |
Comment In:
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J Urol. 1996 Mar;155(3):800-1
[PMID:
8583581
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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