| Testicular seminoma with mediastinal lymphadenopathy -- a diagnostic pitfall. | |
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MedLine Citation:
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PMID: 19386953 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Relapse following adjuvant paraaortic radiation therapy in patients with Stage I seminoma is rare, occurring in approximately 4% of men. The majority of relapses are sited in the pelvis but relapse in the mediastinum is also recognised. As such, radiological imaging using chest radiographs remains commonplace in follow-up. However, there are reports of the association of testicular cancers with sarcoidosis and sarcoid-like processes in the mediastinum, emphasising the importance of making histological diagnosis prior to commencement of any treatment. We report on two men treated for testicular seminoma who on follow-up developed mediastinal lymphadenopathy, which was initially assumed to be metastatic seminoma. Both patients underwent mediastinascopy and biopsy prior to commencement of anti-cancer therapy. In both cases, the biopsies showed sarcoidosis, and unnecessary anti-cancer treatment was avoided. |
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Authors:
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A Jegannathen; M B Taylor; M Jones; J P Logue |
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16049803 - Subfertility and the risk of testicular germ cell tumors (united states). 22496483 - Roles of stromal microenvironment in colon cancer progression. 19581073 - Chemoradiation in gynaecological cancer. |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The British journal of radiology Volume: 82 ISSN: 1748-880X ISO Abbreviation: Br J Radiol Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-04-23 Completed Date: 2009-05-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0373125 Medline TA: Br J Radiol Country: England |
Other Details:
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Languages: eng Pagination: e85-6 Citation Subset: AIM; IM |
Affiliation:
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Departments of Clinical Oncology, Christie Hospital NHS Foundation Trust, Manchester, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biopsy Diagnosis, Differential Humans Lymphatic Diseases / diagnosis, etiology, pathology* Male Mediastinal Diseases / etiology, pathology* Mediastinoscopy Mediastinum / pathology* Sarcoidosis / etiology, pathology* Seminoma / radiotherapy, secondary Testicular Neoplasms / pathology, radiotherapy Tomography, X-Ray Computed |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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