| Testicular peritubular myoid cells are a target for adrenomedullin. | |
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MedLine Citation:
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PMID: 10746866 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Adrenomedullin (AM) is a recently cloned vasorelaxing peptide that belongs to the calcitonin gene-related peptide family. AM inhibits the contraction of several types of smooth muscle cells and is present in the testis as well as in many other organs. The authors investigated whether testicular peritubular myoid cells (PMC) possess specific receptors for AM. Binding of AM to PMC was saturable in a time-dependent manner and 125I-AM binding was effectively displaced by cold AM. The study documents that testicular peritubular myoid cells are a target for adrenomedullin and suggests a role for this peptide in the paracrine regulation of the testis. |
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Authors:
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F Rossi; L Guerrini; G Pasimeni; A Markouizou; A Fabbrini; V Santiemma |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives of andrology Volume: 44 ISSN: 0148-5016 ISO Abbreviation: Arch. Androl. Publication Date: 2000 Mar-Apr |
Date Detail:
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Created Date: 2000-04-28 Completed Date: 2000-04-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7806755 Medline TA: Arch Androl Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 103-7 Citation Subset: IM |
Affiliation:
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Department of Medical Pathophysiology, La Sapienza University of Rome, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenomedullin Animals Cells, Cultured Male Membrane Proteins / metabolism* Peptides / metabolism* Rats Rats, Sprague-Dawley Receptors, Peptide* Seminiferous Tubules / cytology, physiology Testis / cytology, metabolism* Vasodilator Agents / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Membrane Proteins; 0/Peptides; 0/Receptors, Peptide; 0/Vasodilator Agents; 0/adrenomedullin receptor; 148498-78-6/Adrenomedullin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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