Document Detail


Testicular microlithiasis and antisperm antibodies following testicular biopsy in boys with cryptorchidism.
MedLine Citation:
PMID:  16217379     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Testicular biopsy (TBx) performed during orchiopexy in boys with cryptorchidism can help to predict future semen analyses and possibly identify patients at risk for testicular cancer. It has been theorized that TBx can be detrimental to the long-term health of the testis. We examined testicular microlithiasis (TM) and antisperm antibody (ASA) production in cryptorchid TBx. MATERIALS AND METHODS: A total of 112 males underwent fertility evaluation. These patients had previously undergone orchiopexy and bilateral TBx (mean age 8.6 years) for unilateral or bilateral undescended testis. At a mean age of 19.6 years all patients underwent physical examination and scrotal ultrasound for evaluation of testis size, echotexture and abnormalities. Of 112 patients 57 also underwent direct Immunobead(R) assay with positive controls. Moving sperm free and/or bound to IgG bead complex were counted in the preparation. RESULTS: A total of 29 patients had bilateral and 83 had unilateral undescended testis. Of the 112 patients 26 were black and 86 were white. Four black patients (15.4%) and 4 white patients (4.7%) had testicular microlithiasis. Three patients had bilateral and 5 had unilateral diffuse TM. No tunica albuginea scars or testis masses were noted. In the 57 patients who underwent direct Immunobead assay no semen sample demonstrated evidence of forming bead-sperm complex, ie none had direct ASA. CONCLUSIONS: No patient exhibited evidence of direct ASA. Prepubertal open TBx does not increase the rate of TM. We found no evidence of additive testicular damage associated with TBx at the time of orchiopexy.
Authors:
Rakesh P Patel; Thomas F Kolon; Dale S Huff; Michael C Carr; Stephen A Zderic; Douglas A Canning; Howard M Snyder
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of urology     Volume:  174     ISSN:  0022-5347     ISO Abbreviation:  J. Urol.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-11     Completed Date:  2005-11-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376374     Medline TA:  J Urol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2008-10; discussion 2010     Citation Subset:  AIM; IM    
Affiliation:
Division of Urology, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania 19128, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Factors
Autoantibodies / analysis*
Biopsy, Needle / adverse effects,  methods*
Child
Cohort Studies
Cryptorchidism / diagnosis*,  surgery*
Follow-Up Studies
Humans
Immunohistochemistry
Lithiasis / diagnosis*
Male
Predictive Value of Tests
Prospective Studies
Risk Assessment
Testicular Diseases / diagnosis
Urologic Surgical Procedures / methods
Chemical
Reg. No./Substance:
0/Autoantibodies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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