Document Detail

Testicular lesions in Whipple's disease.
MedLine Citation:
PMID:  2579176     Owner:  NLM     Status:  MEDLINE    
In two patients with Whipple's disease a variety of abnormalities were found in the testis. In both there was a thickened tunica albuginea containing macrophages filled with Schiff-positive bacilli, and both exhibited Whipple bacilli alone or in small clumps within the tunica media of the testicular arteries. One patient had focal inflammatory lesions among the Leydig cells. The most prominent abnormality in each was the abundance of Whipple bacilli within the epithelium of the seminiferous tubules. Some of these bacilli (which were free rather than within macrophages) appeared to be being shed into the tubular lumen; there was no associated inflammation. In some areas macrophages filled with bacilli appeared to migrate from the arterial adventitia toward the seminiferous tubules. Potential significance of these findings is discussed relative to a variety of testicular and prostatic diseases, as well as the possible (and arguable) relationship to the acquired immune deficiency syndrome.
T N James; B H Bulkley; H A McAllister; S P Kent
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of laboratory and clinical medicine     Volume:  105     ISSN:  0022-2143     ISO Abbreviation:  J. Lab. Clin. Med.     Publication Date:  1985 Mar 
Date Detail:
Created Date:  1985-04-19     Completed Date:  1985-04-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375375     Medline TA:  J Lab Clin Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  359-67     Citation Subset:  AIM; IM    
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MeSH Terms
Arteries / microbiology
Leydig Cells / microbiology
Macrophages / microbiology
Seminiferous Tubules / microbiology
Sertoli Cells / microbiology
Spermatozoa / pathology
Testis / blood supply,  microbiology*,  pathology,  ultrastructure
Whipple Disease / microbiology*,  pathology
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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