| Testicular lesions in Whipple's disease. | |
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MedLine Citation:
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PMID: 2579176 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In two patients with Whipple's disease a variety of abnormalities were found in the testis. In both there was a thickened tunica albuginea containing macrophages filled with Schiff-positive bacilli, and both exhibited Whipple bacilli alone or in small clumps within the tunica media of the testicular arteries. One patient had focal inflammatory lesions among the Leydig cells. The most prominent abnormality in each was the abundance of Whipple bacilli within the epithelium of the seminiferous tubules. Some of these bacilli (which were free rather than within macrophages) appeared to be being shed into the tubular lumen; there was no associated inflammation. In some areas macrophages filled with bacilli appeared to migrate from the arterial adventitia toward the seminiferous tubules. Potential significance of these findings is discussed relative to a variety of testicular and prostatic diseases, as well as the possible (and arguable) relationship to the acquired immune deficiency syndrome. |
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Authors:
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T N James; B H Bulkley; H A McAllister; S P Kent |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of laboratory and clinical medicine Volume: 105 ISSN: 0022-2143 ISO Abbreviation: J. Lab. Clin. Med. Publication Date: 1985 Mar |
Date Detail:
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Created Date: 1985-04-19 Completed Date: 1985-04-19 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375375 Medline TA: J Lab Clin Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 359-67 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arteries
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microbiology Humans Leydig Cells / microbiology Macrophages / microbiology Male Seminiferous Tubules / microbiology Sertoli Cells / microbiology Spermatozoa / pathology Testis / blood supply, microbiology*, pathology, ultrastructure Whipple Disease / microbiology*, pathology |
| Grant Support | |
ID/Acronym/Agency:
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HL 11310/HL/NHLBI NIH HHS; HL 17667/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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