| Testicular intravascular volume and microvessel mitotic activity: effect of experimental varicocele. | |
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MedLine Citation:
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PMID: 8407573 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Testicular blood flow increases bilaterally in animals with experimental left varicocele (ELV). The present experiments were undertaken to determine if increases in testicular intravascular volume and capillary growth were potential contributors to this increase in flow. Testicular intravascular volume (microliters/g) was estimated by determining testicular vascular 125I-albumin space. Microvessel mitotic activity was estimated by examining 3H-thymidine incorporation into endothelial nuclei, as assayed by silver grain localization over microvessel endothelial nuclei after exposure of testes to 3H-thymidine in vivo. Testicular intravascular volume was 25-30 microliters/g testis in control testes and in ELV animals was increased an average of 9% and 28% in right and left testes, respectively. This increase was statistically significant (P < 0.05) on the left side only. Approximately 1.5-2.0% of testicular microvessel endothelial nuclei exhibited silver grain localization, and ELV was not associated with a change in these values in either right or left testis. Ancillarily, there was a modest but significant association between microvessel mitotic activity and mitotic activity in adjacent seminiferous tubules. It was concluded that bilateral increases in testicular blood flow after ELV are not uniquely the result of bilateral expansion of intravascular volume and growth of the testicular capillaries. It is speculated, however, that mitogenic factors from the seminiferous tubules potentially affect mitotic activity of the adjacent microvasculature. |
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Authors:
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T T Turner; K J Brown; C L Spann |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of andrology Volume: 14 ISSN: 0196-3635 ISO Abbreviation: J. Androl. Publication Date: 1993 May-Jun |
Date Detail:
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Created Date: 1993-11-01 Completed Date: 1993-11-01 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8106453 Medline TA: J Androl Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 180-6 Citation Subset: IM |
Affiliation:
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Department of Urology, University of Virginia Health Sciences Center, Charlottesville 22908. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Capillaries / pathology DNA / biosynthesis Disease Models, Animal Endothelium, Vascular / pathology Male Mitosis* Rats Rats, Sprague-Dawley Serum Albumin, Radio-Iodinated / diagnostic use Testis / blood supply* Thymidine / metabolism Time Factors Tritium / diagnostic use Varicocele / pathology* |
| Grant Support | |
ID/Acronym/Agency:
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HD-18252/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Serum Albumin, Radio-Iodinated; 10028-17-8/Tritium; 50-89-5/Thymidine; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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