Document Detail

Testicular effects of acrylonitrile in mice.
MedLine Citation:
PMID:  3388448     Owner:  NLM     Status:  MEDLINE    
Daily oral administration of acrylonitrile (10 mg/kg body weight) to mice for a period of 60 days caused a significant decrease in the activity of testicular sorbitol dehydrogenase and acid phosphatase, and an increase in that of lactate dehydrogenase and beta-glucuronidase. Histopathological studies revealed degeneration of the seminiferous tubules. A decrease in the sperm counts of the epididymal spermatozoa was also observed in the animals of the acrylonitrile-exposed group. These observations suggest that acrylonitrile may affect the male reproductive function by causing testicular injury.
R Tandon; D K Saxena; S V Chandra; P K Seth; S P Srivastava
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Toxicology letters     Volume:  42     ISSN:  0378-4274     ISO Abbreviation:  Toxicol. Lett.     Publication Date:  1988 Jul 
Date Detail:
Created Date:  1988-08-01     Completed Date:  1988-08-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7709027     Medline TA:  Toxicol Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  55-63     Citation Subset:  IM    
Industrial Toxicology Research Centre, Mahatma Gandhi Marg, Lucknow, India.
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MeSH Terms
Acid Phosphatase / antagonists & inhibitors
Acrylonitrile / toxicity*
Glucosephosphate Dehydrogenase / metabolism
Glucuronidase / metabolism
L-Iditol 2-Dehydrogenase / antagonists & inhibitors
L-Lactate Dehydrogenase / metabolism
Nitriles / toxicity*
Seminiferous Tubules / drug effects,  pathology
Sperm Count / drug effects
Spermatogenesis / drug effects
Testis / drug effects*,  enzymology,  pathology
Reg. No./Substance:
0/Nitriles; 107-13-1/Acrylonitrile; EC 2-Dehydrogenase; EC Dehydrogenase; EC Dehydrogenase; EC Phosphatase; EC

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