| Testicular effects of acrylonitrile in mice. | |
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MedLine Citation:
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PMID: 3388448 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Daily oral administration of acrylonitrile (10 mg/kg body weight) to mice for a period of 60 days caused a significant decrease in the activity of testicular sorbitol dehydrogenase and acid phosphatase, and an increase in that of lactate dehydrogenase and beta-glucuronidase. Histopathological studies revealed degeneration of the seminiferous tubules. A decrease in the sperm counts of the epididymal spermatozoa was also observed in the animals of the acrylonitrile-exposed group. These observations suggest that acrylonitrile may affect the male reproductive function by causing testicular injury. |
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Authors:
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R Tandon; D K Saxena; S V Chandra; P K Seth; S P Srivastava |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Toxicology letters Volume: 42 ISSN: 0378-4274 ISO Abbreviation: Toxicol. Lett. Publication Date: 1988 Jul |
Date Detail:
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Created Date: 1988-08-01 Completed Date: 1988-08-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7709027 Medline TA: Toxicol Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 55-63 Citation Subset: IM |
Affiliation:
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Industrial Toxicology Research Centre, Mahatma Gandhi Marg, Lucknow, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acid Phosphatase
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antagonists & inhibitors Acrylonitrile / toxicity* Animals Glucosephosphate Dehydrogenase / metabolism Glucuronidase / metabolism L-Iditol 2-Dehydrogenase / antagonists & inhibitors L-Lactate Dehydrogenase / metabolism Male Mice Nitriles / toxicity* Seminiferous Tubules / drug effects, pathology Sperm Count / drug effects Spermatogenesis / drug effects Testis / drug effects*, enzymology, pathology |
| Chemical | |
Reg. No./Substance:
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0/Nitriles; 107-13-1/Acrylonitrile; EC 1.1.1.14/L-Iditol 2-Dehydrogenase; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 1.1.1.49/Glucosephosphate Dehydrogenase; EC 3.1.3.2/Acid Phosphatase; EC 3.2.1.31/Glucuronidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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