Document Detail

Testicular dysfunction after cyclophosphamide-vincristine-procarbazine-prednisolone chemotherapy for advanced Hodgkin's disease. A long-term follow-up study.
MedLine Citation:
PMID:  2115396     Owner:  NLM     Status:  MEDLINE    
Gonadal functions were evaluated in 92 male patients after treatment for advanced Hodgkin's disease. The patients received six to ten cycles of cyclophosphamide, vincristine, procarbazine, and prednisolone (COPP) chemotherapy. All patients were in remission and were followed for 1 to 17 years (median, 6). Testicular atrophy was noticed in 89 (96.7%) patients. All patients remained azoospermic during the period of follow-up. The testosterone levels did not differ before and after treatment. The follicle stimulating hormone levels rose from pretreatment values (mean +/- standard deviation) of 179.27 +/- 21.99 ng/ml to 578.79 +/- 102.36 ng/ml after the treatment; the rise was significant (P less than 0.001). The luteinizing hormone levels rose from pretreatment values of 106.96 +/- 20.37 ng/ml to 127.37 +/- 32.19 ng/ml after treatment; the rise was significant (P less than 0.05). Testicular biopsy specimens in 19 patients showed germinal aplasia in all cases. It is concluded that six or more cycles of COPP chemotherapy for advanced Hodgkin's disease in men leads to permanent sterility.
B S Charak; R Gupta; P Mandrekar; N A Sheth; S D Banavali; T K Saikia; R Gopal; K A Dinshaw; S H Advani
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer     Volume:  65     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-08-28     Completed Date:  1990-08-28     Revised Date:  2006-04-24    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1903-6     Citation Subset:  AIM; IM    
Department of Medical Oncology, Tata Memorial Hospital, Bombay, India.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / adverse effects*
Cyclophosphamide / administration & dosage
Follicle Stimulating Hormone / blood
Follow-Up Studies
Hodgkin Disease / blood,  drug therapy*
Infertility, Male / chemically induced*
Luteinizing Hormone / blood
Prednisolone / administration & dosage
Procarbazine / administration & dosage
Testis / drug effects*,  physiopathology
Testosterone / blood
Vincristine / administration & dosage
Reg. No./Substance:
50-18-0/Cyclophosphamide; 50-24-8/Prednisolone; 57-22-7/Vincristine; 58-22-0/Testosterone; 671-16-9/Procarbazine; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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