Document Detail

Testicular changes in newborn rats exposed to phototherapy.
MedLine Citation:
PMID:  10347276     Owner:  NLM     Status:  MEDLINE    
In this study we investigated the long-term effects of 72-h continuous phototherapy on the reproductive system of newborn rats. The animals' weight, fertilization rates, and number of newborn and histopathological changes in the gonads in a normal group not exposed to phototherapy and in the test animals were compared. At the age of 24 weeks there were no significant differences between the two groups, apart from the histology of the testicles of the male rats who were exposed to the phototherapy. The study group showed a significantly reduced diameter of the seminiferous tubules when compared to the controls (P < 0.001). It can be postulated that phototherapy may cause histological degenerative changes in the structure of the rat's testes, even though there were no changes in fertilization rates. Further studies are necessary to reveal the effects of phototherapy on humans and to determine the effects, if any, on fertility.
H Koç; H Altunhan; A Dilsiz; A Kaymakçi; S Duman; B Oran; I Erkul
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society     Volume:  2     ISSN:  1093-5266     ISO Abbreviation:  Pediatr. Dev. Pathol.     Publication Date:    1999 Jul-Aug
Date Detail:
Created Date:  1999-07-16     Completed Date:  1999-07-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9809673     Medline TA:  Pediatr Dev Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  333-6     Citation Subset:  IM    
Department of Pediatrics, Faculty of Medicine, University of Selçuk, 42080 Konya, Turkey.
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MeSH Terms
Animals, Newborn
Body Temperature
Body Weight / radiation effects
Fertility / radiation effects
Litter Size
Ovary / pathology,  radiation effects
Phototherapy / adverse effects*
Radiation Injuries, Experimental / etiology*,  pathology
Rats, Wistar
Seminiferous Tubules / pathology,  radiation effects
Testicular Diseases / etiology*,  pathology
Testis / pathology,  radiation effects*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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