Document Detail


Testicular cancer.
MedLine Citation:
PMID:  2672228     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The management of testis cancer is continually changing. Since the introduction of curative chemotherapy for metastatic disease, the entire approach to early disease (stage I and stage II) is undergoing reevaluation. Individuals with favorable prognostic features can be offered, under detailed clinical protocols, orchiectomy followed by meticulous surveillance. Likewise, individuals with retroperitoneal disease may be offered retroperitoneal lymph node dissection initially or, alternatively, chemotherapy initially. The prognosis for individuals with metastatic disease is extremely favorable, with the majority of patients being cured with 9-12 weeks of combination chemotherapy. Major efforts are still underway to identify appropriate second-line or "salvage" regimens for individuals who are not cured with first-line chemotherapy. Likewise, the use of new modalities, such as bone marrow transplantation, and new drugs must be evaluated in appropriately designed, prospective studies. Such studies will continue to increase the cure rate of individuals with metastatic disease and enhance the prognosis for such high-risk populations of patients. This paper reviews basic aspects relating to histology, clinical staging, and approach to management for all stages of germ cell cancer of the testis.
Authors:
M B Garnick
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in surgical oncology     Volume:  5     ISSN:  8756-0437     ISO Abbreviation:  Semin Surg Oncol     Publication Date:  1989  
Date Detail:
Created Date:  1989-09-26     Completed Date:  1989-09-26     Revised Date:  2006-04-24    
Medline Journal Info:
Nlm Unique ID:  8503713     Medline TA:  Semin Surg Oncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  221-6     Citation Subset:  IM    
Affiliation:
Department of Medicine, Dana-Farber Cancer Institute, Harvard Medical School, Cambridge, Massachusetts.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Combined Modality Therapy
Humans
Male
Neoplasm Staging
Orchiectomy
Radiotherapy
Testicular Neoplasms / diagnosis,  pathology,  therapy*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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