| Testicular blood flow and vasomotion can be maintained by testosterone in Leydig cell-depleted rats. | |
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MedLine Citation:
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PMID: 1428197 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of testosterone supplementation on testicular blood flow, testicular vasomotion, the number of polymorphonuclear leucocytes (PMN's) in testicular blood vessels and prostatic blood flow were studied in rats in which the Leydig cell had been destroyed specifically by a single injection of ethane dimethylsulfonate (EDS). Other rats were supplemented with testosterone by subcutaneous injection of 25 mg testosterone propionate on days 1, 3 and 6. In some experiments, the effect of a single injection of 25 or 125 mg testosterone was studied. Testicular and prostatic blood flow and the number of PMN's in testicular blood vessels decreased, and vasomotion disappeared in Leydig cell-depleted rats, but testosterone supplementation restored all parameters to normal values. Moreover, a single injection of testosterone was able to restore testicular and prostatic blood flow to normal levels but had an inconsistent effect on vasomotion. These results suggest that testosterone may play a role in the physiological control of the testicular microcirculation. |
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Authors:
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J E Damber; S Maddocks; A Widmark; A Bergh |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of andrology Volume: 15 ISSN: 0105-6263 ISO Abbreviation: Int. J. Androl. Publication Date: 1992 Oct |
Date Detail:
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Created Date: 1992-12-04 Completed Date: 1992-12-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8000141 Medline TA: Int J Androl Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 385-93 Citation Subset: IM |
Affiliation:
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Department of Urology & Andrology, University of Umeå, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Leydig Cells / drug effects, physiology* Male Organ Size Rats Rats, Sprague-Dawley Regional Blood Flow Testis / blood supply*, metabolism, physiology Testosterone / blood, metabolism, physiology |
| Chemical | |
Reg. No./Substance:
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58-22-0/Testosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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