| Testicular Volume and Testicular Microlithiasis in Boys With Down Syndrome. | |
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MedLine Citation:
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PMID: 22264460 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: Studies have suggested that testicular microlithiasis and Down syndrome are linked, yet a correlation remains unclear. We investigated the prevalence of testicular microlithiasis in patients with Down syndrome. We hypothesized that testicular microlithiasis is present at a higher rate in these patients. We further hypothesized that patients with Down syndrome have lower testicular volumes than normal age matched boys. We tested our hypothesis by ultrasound investigation in boys 0 to 18 years old with Down syndrome. MATERIALS AND METHODS: Testicular ultrasound was performed in 79 boys with Down syndrome. Mean patient age was 8.8 years (range 0.4 to 18.3). Testicular microlithiasis was assessed and testicular volume was measured according to the formula, π/6 × length × width × height. RESULTS: Testicular microlithiasis was present in 18 boys (22.8%). It was diagnosed in 6 of 28 boys younger than 7 years (21.4%), in 6 of 28 boys 7 to 12 years (21.4%) and in 6 of 23 boys 12 years or older (26.1%). No significant difference was found in the prevalence of testicular microlithiasis between these 3 groups. Mean testicular volumes in patients with Down syndrome (2.19 ml) were significantly smaller than the normative values. CONCLUSIONS: This study demonstrated a 22.8% prevalence of testicular microlithiasis in boys with Down syndrome, which is significantly increased compared to normative values. In addition, testis volume is significantly smaller in boys with Down syndrome compared to normative values. |
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Authors:
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Joery Goede; Michel E Weijerman; Chantal J M Broers; J Peter de Winter; Laszla M van der Voort-Doedens; Wilfried W M Hack |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-18 |
Journal Detail:
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Title: The Journal of urology Volume: - ISSN: 1527-3792 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376374 Medline TA: J Urol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Pediatrics, Medical Center Alkmaar, Alkmaar, The Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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