Document Detail

Testicular Ca++ ATPase activity in mice: effects of age and gonadotropin administration.
MedLine Citation:
PMID:  2963937     Owner:  NLM     Status:  MEDLINE    
These studies describe a high affinity calcium (Ca++)-dependent ATPase in purified testicular plasma membranes, which exhibits increased activity from weaning age to adulthood. Administration of human chorionic gonadotropin (hCG; 5 IU) increased enzyme activity in 21-day old and pubertal (35 to 40-day old), but not in adult mice. In pubertal mice, these increases in testicular Ca++-ATPase activity were dose-related and evident 60 min after hCG administration. A second challenge dose of 5 IU hCG administered either 24, 48 hrs, or 5 days later, had no additional effect on Ca++ ATPase in purified testicular plasma membranes in these pubertal animals. The present findings indicate that testicular plasma membrane Ca++ATPase activity exhibits a developmental pattern concomitant with increased testicular steroidogenic activity during sexual maturation. Furthermore, enzyme activity is increased by gonadotropic stimulation and exhibits a refractoriness similar to that of androgen biosynthesis to repeated hCG stimulation.
S Dalterio; C Esquivel; S Bernard; V Gandhi
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Life sciences     Volume:  42     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1988  
Date Detail:
Created Date:  1988-03-29     Completed Date:  1988-03-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  969-77     Citation Subset:  IM    
Department of Pharmacology, University of Texas Health Science Center, San Antonio 78284-7764.
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MeSH Terms
Aging / metabolism*
Calcium-Transporting ATPases / metabolism*
Cell Membrane / enzymology
Chorionic Gonadotropin / pharmacology*
Testis / enzymology*,  metabolism
Testosterone / metabolism
Reg. No./Substance:
0/Chorionic Gonadotropin; 58-22-0/Testosterone; EC ATPases

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