| Testican 3 expression in adult T-cell leukemia. | |
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MedLine Citation:
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PMID: 19144404 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Adult T-cell leukemia (ATL) is an aggressive disease characterized by visceral invasion, and ATL regulates matrix metalloproteinase (MMP) activities of the endothelial cells. The controlling system of MMP activities in ATL is regulated by various factors such as Emmprin and tissue inhibitor of MMP. In this study, we demonstrated that Testican 3 expression in ATL decreased the activity of MMP. Furthermore, we showed that the expression of Testican 3 was regulated by activating transcriptional factor 3 in human T-lymphotropic virus type I-related cell lines. Thus, Testican 3 is a novel regulator to reduce the activity of MMP in ATL. |
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Authors:
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Mikio Kamioka; Jun Imamura; Naoki Komatsu; Masanori Daibata; Tetsuro Sugiura |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-01-13 |
Journal Detail:
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Title: Leukemia research Volume: 33 ISSN: 1873-5835 ISO Abbreviation: Leuk. Res. Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-05-05 Completed Date: 2009-05-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7706787 Medline TA: Leuk Res Country: England |
Other Details:
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Languages: eng Pagination: 913-8 Citation Subset: IM |
Affiliation:
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Department of Laboratory Medicine, Kochi University, Kochi 783-8505, Japan. mkamioka@kochi-u.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Activating Transcription Factor 3
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genetics,
metabolism* Adult Anisomycin / pharmacology Blotting, Western Cell Line, Transformed Human T-lymphotropic virus 1 / genetics Humans Leukemia-Lymphoma, Adult T-Cell / genetics*, metabolism, pathology Matrix Metalloproteinase 2 / antagonists & inhibitors*, metabolism Matrix Metalloproteinase 9 / antagonists & inhibitors*, metabolism Protein Synthesis Inhibitors / pharmacology Proteoglycans / genetics*, metabolism RNA, Messenger / genetics, metabolism RNA, Small Interfering / pharmacology Reverse Transcriptase Polymerase Chain Reaction Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
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0/ATF3 protein, human; 0/Activating Transcription Factor 3; 0/Protein Synthesis Inhibitors; 0/Proteoglycans; 0/RNA, Messenger; 0/RNA, Small Interfering; 0/SPOCK3 protein, human; 22862-76-6/Anisomycin; EC 3.4.24.24/Matrix Metalloproteinase 2; EC 3.4.24.35/Matrix Metalloproteinase 9 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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