Document Detail


Testican 3 expression in adult T-cell leukemia.
MedLine Citation:
PMID:  19144404     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adult T-cell leukemia (ATL) is an aggressive disease characterized by visceral invasion, and ATL regulates matrix metalloproteinase (MMP) activities of the endothelial cells. The controlling system of MMP activities in ATL is regulated by various factors such as Emmprin and tissue inhibitor of MMP. In this study, we demonstrated that Testican 3 expression in ATL decreased the activity of MMP. Furthermore, we showed that the expression of Testican 3 was regulated by activating transcriptional factor 3 in human T-lymphotropic virus type I-related cell lines. Thus, Testican 3 is a novel regulator to reduce the activity of MMP in ATL.
Authors:
Mikio Kamioka; Jun Imamura; Naoki Komatsu; Masanori Daibata; Tetsuro Sugiura
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-01-13
Journal Detail:
Title:  Leukemia research     Volume:  33     ISSN:  1873-5835     ISO Abbreviation:  Leuk. Res.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-05-05     Completed Date:  2009-05-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7706787     Medline TA:  Leuk Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  913-8     Citation Subset:  IM    
Affiliation:
Department of Laboratory Medicine, Kochi University, Kochi 783-8505, Japan. mkamioka@kochi-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Activating Transcription Factor 3 / genetics,  metabolism*
Adult
Anisomycin / pharmacology
Blotting, Western
Cell Line, Transformed
Human T-lymphotropic virus 1 / genetics
Humans
Leukemia-Lymphoma, Adult T-Cell / genetics*,  metabolism,  pathology
Matrix Metalloproteinase 2 / antagonists & inhibitors*,  metabolism
Matrix Metalloproteinase 9 / antagonists & inhibitors*,  metabolism
Protein Synthesis Inhibitors / pharmacology
Proteoglycans / genetics*,  metabolism
RNA, Messenger / genetics,  metabolism
RNA, Small Interfering / pharmacology
Reverse Transcriptase Polymerase Chain Reaction
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/ATF3 protein, human; 0/Activating Transcription Factor 3; 0/Protein Synthesis Inhibitors; 0/Proteoglycans; 0/RNA, Messenger; 0/RNA, Small Interfering; 0/SPOCK3 protein, human; 22862-76-6/Anisomycin; EC 3.4.24.24/Matrix Metalloproteinase 2; EC 3.4.24.35/Matrix Metalloproteinase 9

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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