| Test-retest reliability and reproducibility of short-echo-time spectroscopic imaging of human brain at 3T. | |
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MedLine Citation:
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PMID: 21360748 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A (1) H magnetic resonance spectroscopic imaging study at 3T and short echo time was conducted to evaluate both the reproducibility, as measured by the interscan coefficient of variation (CV), and test-retest reliability, as measured by the intraclass correlation coefficient (ICC), of measurements of glutamate (Glu), combined glutamate and glutamine (Glx), myo-inositol (mI), N-acetylaspartate, creatine, and choline in 21 healthy subjects. The effect of partial volume correction on these measures and the relationship of reproducibility and reliability to data quality were also examined. A (1) H magnetic resonance spectroscopic imaging slice was prescribed above the lateral ventricles and single repeat scans were performed within 30 min to minimize physiologic variability. Interscan CVs based on all the voxels varied from 0.05 to 0.07 for N-acetylaspartate, creatine, and choline to 0.10-0.13 for mI, Glu, and Glx. Findings on the reproducibility of gray and white matter estimates of N-acetylaspartate, creatine, and choline are consistent with previous studies using longer echo times, with CVs in the range of 0.02-0.04 and ICC in the range of 0.65-0.90. CVs for Glu, Glx, and mI are much lower than reported in previous studies at 1.5T, while white matter mI (CV = 0.04, ICC = 0.93) and gray matter Glx (CV = 0.04, ICC = 0.68) demonstrated both high reproducibility and test-retest reliability. Magn Reson Med, 2011. © 2011 Wiley-Liss, Inc. |
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Authors:
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Charles Gasparovic; Edward J Bedrick; Andrew R Mayer; Ronald A Yeo; Hongji Chen; Eswar Damaraju; Vince D Calhoun; Rex E Jung |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-28 |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: - ISSN: 1522-2594 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-3-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Wiley-Liss, Inc. |
Affiliation:
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The Mind Research Network, Albuquerque, New Mexico, USA; Department of Psychology, University of New Mexico, Albuquerque, New Mexico, USA. chuck@mrn.org. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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