| Test-retest reliability of pulse amplitude tonometry measures of vascular endothelial function: implications for clinical trial design. | |
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MedLine Citation:
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PMID: 22363016 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Endothelial dysfunction is an important outcome for assessing vascular health in intervention studies. However, reliability of the standard non-invasive method (flow-mediated dilation) is a significant challenge for clinical applications and multicenter trials. We evaluated the repeatability of pulse amplitude tonometry (PAT) to measure change in pulse wave amplitude during reactive hyperemia (Itamar Medical Ltd, Caesarea, Israel). Twenty healthy adults completed two PAT tests (mean interval = 19.5 days) under standardized conditions. PAT-derived measures of endothelial function (reactive hyperemia index, RHI) and arterial stiffness (augmentation index, AI) showed strong repeatability (intra-class correlations = 0.74 and 0.83, respectively). To guide future research, we also analyzed sample size requirements for a range of effect sizes. A crossover design powered at 0.90 requires 28 participants to detect a 15% change in RHI. Our study is the first to show that PAT measurements are repeatable in adults over an interval greater than 1 week. |
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Authors:
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Cindy E McCrea; Ann C Skulas-Ray; Mosuk Chow; Sheila G West |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Vascular medicine (London, England) Volume: 17 ISSN: 1477-0377 ISO Abbreviation: Vasc Med Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-02-24 Completed Date: 2012-06-20 Revised Date: 2013-04-01 |
Medline Journal Info:
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Nlm Unique ID: 9610930 Medline TA: Vasc Med Country: England |
Other Details:
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Languages: eng Pagination: 29-36 Citation Subset: IM |
Affiliation:
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Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Endothelium, Vascular / physiology* Female Humans Male Manometry / methods* Middle Aged Reproducibility of Results Research Design Vascular Stiffness / physiology |
| Grant Support | |
ID/Acronym/Agency:
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M01 RR 10732/RR/NCRR NIH HHS; M01 RR010732/RR/NCRR NIH HHS; UL1 TR000127/TR/NCATS NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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