| Test of cure for genital Chlamydia trachomatis infection in women. | |
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MedLine Citation:
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PMID: 2362173 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Convenient, reliable tests of cure for genital chlamydial infections have not been evaluated. Cervical appearance, endocervical Gram stain, enzyme immunoassay, and culture for Chlamydia trachomatis were evaluated during a pretreatment visit and at two subsequent randomized test-of-cure visits for 64 nongravid women with endocervical C trachomatis of 3544 patients screened. There were no useful correlations between C trachomatis resolution and cervical appearance. Endocervical Gram stain was determined to be unreliable for test-of-cure use. Both C trachomatis culture and enzyme-linked immunosorbent assay (ELISA) were shown to be effective for test-of-cure evaluation. The ELISA test became reliably negative 10 days after initiation of treatment and 1 to 5 days after the clearance of viable organisms detected by culture (P = .03). Convenience and cost considerations favor antigen detection methods. This study suggests that antigen detection methods can be used for situations in which test of cure is indicated, such as therapy noncompliance, circumstances supporting reinfection, pregnancy, complicated infections, requests for psychological reassurance, and evidence of persistent cervicitis. |
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Authors:
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D G Ferris; F H Lawler; R D Horner; J C Jernigan; F V Crout |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of family practice Volume: 31 ISSN: 0094-3509 ISO Abbreviation: J Fam Pract Publication Date: 1990 Jul |
Date Detail:
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Created Date: 1990-08-08 Completed Date: 1990-08-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7502590 Medline TA: J Fam Pract Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 36-41 Citation Subset: AIM; IM |
Affiliation:
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Student Health Service, Medical College of Georgia, Augusta 30912. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chlamydia Infections
/
diagnosis*,
drug therapy,
pathology Chlamydia trachomatis / isolation & purification Enzyme-Linked Immunosorbent Assay Female Humans Tetracycline / therapeutic use Uterine Cervicitis / diagnosis*, drug therapy, etiology, pathology |
| Chemical | |
Reg. No./Substance:
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60-54-8/Tetracycline |
| Comments/Corrections | |
Comment In:
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J Fam Pract. 1990 Oct;31(4):353, 356
[PMID:
2212962
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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