| Terpenoids. III: Synthesis and biological evaluation of 23-hydroxybetulinic acid derivatives as novel inhibitors of glycogen phosphorylase. | |
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MedLine Citation:
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PMID: 19889536 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A series of 23-hydroxybetulinic acid derivatives were prepared and tested in vitro as a new class of inhibitors of glycogen phosphorylase (GP). Within this series of compounds, 12b (IC(50)=3.5 microM) is the most potent GPa inhibitor. The preliminary SAR results of the 23-hydroxybetulinic acid derivatives are discussed. |
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Authors:
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Peiqing Zhu; Yi Bi; Jinyi Xu; Zan Li; Jun Liu; Luyong Zhang; Wencai Ye; Xiaoming Wu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-11-02 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry letters Volume: 19 ISSN: 1464-3405 ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-16 Completed Date: 2010-02-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: England |
Other Details:
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Languages: eng Pagination: 6966-9 Citation Subset: IM |
Affiliation:
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Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tongjia Xiang, Nanjing, Jiangsu 210009, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Drug Design Enzyme Inhibitors / chemical synthesis, chemistry*, pharmacology Glycogen Phosphorylase / antagonists & inhibitors* Humans Rabbits Structure-Activity Relationship Triterpenes / chemical synthesis, chemistry*, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/23-hydroxybetulinic acid; 0/Enzyme Inhibitors; 0/Triterpenes; EC 2.4.1.-/Glycogen Phosphorylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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