Document Detail


Terpenoids. III: Synthesis and biological evaluation of 23-hydroxybetulinic acid derivatives as novel inhibitors of glycogen phosphorylase.
MedLine Citation:
PMID:  19889536     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A series of 23-hydroxybetulinic acid derivatives were prepared and tested in vitro as a new class of inhibitors of glycogen phosphorylase (GP). Within this series of compounds, 12b (IC(50)=3.5 microM) is the most potent GPa inhibitor. The preliminary SAR results of the 23-hydroxybetulinic acid derivatives are discussed.
Authors:
Peiqing Zhu; Yi Bi; Jinyi Xu; Zan Li; Jun Liu; Luyong Zhang; Wencai Ye; Xiaoming Wu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-11-02
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  19     ISSN:  1464-3405     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-16     Completed Date:  2010-02-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  6966-9     Citation Subset:  IM    
Affiliation:
Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tongjia Xiang, Nanjing, Jiangsu 210009, China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Drug Design
Enzyme Inhibitors / chemical synthesis,  chemistry*,  pharmacology
Glycogen Phosphorylase / antagonists & inhibitors*
Humans
Rabbits
Structure-Activity Relationship
Triterpenes / chemical synthesis,  chemistry*,  pharmacology
Chemical
Reg. No./Substance:
0/23-hydroxybetulinic acid; 0/Enzyme Inhibitors; 0/Triterpenes; EC 2.4.1.-/Glycogen Phosphorylase

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