Document Detail

Terpenoid metabolites from Spongia spp. and their effects on nucleic acid biosynthesis in sea urchin eggs.
MedLine Citation:
PMID:  21815408     Owner:  NLM     Status:  In-Process    
19-Norspongia-13(16),14-diene-3-one (1) was isolated for the first time from a natural source, along with a series of known spongiane diterpenoids (2-11) and sesquiterpene (12) from two unidentified species belonging to the genus Spongia. The effects of 1, 4, 5, 8-12 on biosynthesis of nucleic acids and embryonic development of the sea urchin Strongylocentrotus intermedius have been studied. All the compounds inhibit sea urchin embryo development at concentration of 20 microg/mL and above and DNA biosynthesis at the dose of 10 microg/mL. The inhibitory effect of diterpenoids at least partly may be explained by the inhibition of thymidine kinase activity.
Ludmila P Ponomarenko; Natalia A Terent'eva; Vladimir B Krasokhin; Anatoliy I Kalinovsky; Valery A Rasskazov
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Natural product communications     Volume:  6     ISSN:  1934-578X     ISO Abbreviation:  Nat Prod Commun     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-08-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101477873     Medline TA:  Nat Prod Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  773-6     Citation Subset:  IM    
Pacific Institute of Bioorganic Chemistry, FEB RAS, pr. 100 let Vladivostoku, 159, Vladivostok 690022, Russian Federation.
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