| Terpenoid metabolites from Spongia spp. and their effects on nucleic acid biosynthesis in sea urchin eggs. | |
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MedLine Citation:
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PMID: 21815408 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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19-Norspongia-13(16),14-diene-3-one (1) was isolated for the first time from a natural source, along with a series of known spongiane diterpenoids (2-11) and sesquiterpene (12) from two unidentified species belonging to the genus Spongia. The effects of 1, 4, 5, 8-12 on biosynthesis of nucleic acids and embryonic development of the sea urchin Strongylocentrotus intermedius have been studied. All the compounds inhibit sea urchin embryo development at concentration of 20 microg/mL and above and DNA biosynthesis at the dose of 10 microg/mL. The inhibitory effect of diterpenoids at least partly may be explained by the inhibition of thymidine kinase activity. |
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Authors:
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Ludmila P Ponomarenko; Natalia A Terent'eva; Vladimir B Krasokhin; Anatoliy I Kalinovsky; Valery A Rasskazov |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Natural product communications Volume: 6 ISSN: 1934-578X ISO Abbreviation: Nat Prod Commun Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-08-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101477873 Medline TA: Nat Prod Commun Country: United States |
Other Details:
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Languages: eng Pagination: 773-6 Citation Subset: IM |
Affiliation:
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Pacific Institute of Bioorganic Chemistry, FEB RAS, pr. 100 let Vladivostoku, 159, Vladivostok 690022, Russian Federation. ponomarenko@piboc.dvo.ru |
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