Document Detail

Terpenoid metabolites from Spongia spp. and their effects on nucleic acid biosynthesis in sea urchin eggs.
MedLine Citation:
PMID:  21815408     Owner:  NLM     Status:  In-Process    
19-Norspongia-13(16),14-diene-3-one (1) was isolated for the first time from a natural source, along with a series of known spongiane diterpenoids (2-11) and sesquiterpene (12) from two unidentified species belonging to the genus Spongia. The effects of 1, 4, 5, 8-12 on biosynthesis of nucleic acids and embryonic development of the sea urchin Strongylocentrotus intermedius have been studied. All the compounds inhibit sea urchin embryo development at concentration of 20 microg/mL and above and DNA biosynthesis at the dose of 10 microg/mL. The inhibitory effect of diterpenoids at least partly may be explained by the inhibition of thymidine kinase activity.
Ludmila P Ponomarenko; Natalia A Terent'eva; Vladimir B Krasokhin; Anatoliy I Kalinovsky; Valery A Rasskazov
Related Documents :
6417118 - Characterization of two forms of base non-specific and adenylic acid preferential ribon...
22919298 - Different accumulation of free amino acids during short- and long-term osmotic stress i...
17875998 - Biochemical characterization of sfc-1, a class a carbapenem-hydrolyzing beta-lactamase.
7076828 - Isolation and identification of paramyosin from amphioxus notochord.
25477678 - "effect of sorbic acid on the storage quality of kaladhi-an acid coagulated milk product"
8212048 - Purification, sequencing and characterization of single amino acid-substituted phosphol...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Natural product communications     Volume:  6     ISSN:  1934-578X     ISO Abbreviation:  Nat Prod Commun     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-08-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101477873     Medline TA:  Nat Prod Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  773-6     Citation Subset:  IM    
Pacific Institute of Bioorganic Chemistry, FEB RAS, pr. 100 let Vladivostoku, 159, Vladivostok 690022, Russian Federation.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Lipophilic components from the Ecuadorian plant Schistocarpha eupatorioides.
Next Document:  Evaluation of ent-kaurenoic acid derivatives for their anticariogenic activity.