Document Detail

Terpenes with antimicrobial activity from Cretan propolis.
MedLine Citation:
PMID:  19698962     Owner:  NLM     Status:  MEDLINE    
Five terpenes, the diterpenes: 14,15-dinor-13-oxo-8(17)-labden-19-oic acid and a mixture of labda-8(17),13E-dien-19-carboxy-15-yl oleate and palmitate as well as the triterpenes, 3,4-seco-cycloart-12-hydroxy-4(28),24-dien-3-oic acid and cycloart-3,7-dihydroxy-24-en-28-oic acid were isolated from Cretan propolis. Moreover, 18 known compounds were also isolated, seven of them for the first time as propolis components. All structures were established on the basis of spectroscopic analysis and chemical evidence. All isolated compounds were tested for antimicrobial activity against some Gram-positive and Gram-negative bacteria as well as against some human pathogenic fungi showing a broad spectrum of antimicrobial activity.
Milena P Popova; Ioanna B Chinou; Ilko N Marekov; Vassya S Bankova
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-08-19
Journal Detail:
Title:  Phytochemistry     Volume:  70     ISSN:  1873-3700     ISO Abbreviation:  Phytochemistry     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-09-01     Completed Date:  2009-11-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0151434     Medline TA:  Phytochemistry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1262-71     Citation Subset:  IM    
Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev Str. Bl. 9, 1113 Sofia, Bulgaria.
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MeSH Terms
Anti-Bacterial Agents / chemistry*,  pharmacology*
Antifungal Agents / chemistry*,  pharmacology*
Candida / drug effects
Diterpenes / chemistry,  pharmacology
Gram-Negative Bacteria / drug effects
Gram-Positive Bacteria / drug effects
Magnetic Resonance Spectroscopy
Molecular Structure
Plant Extracts / chemistry,  pharmacology
Propolis / chemistry*
Terpenes / chemistry*,  pharmacology*
Triterpenes / chemistry,  pharmacology
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Antifungal Agents; 0/Diterpenes; 0/Plant Extracts; 0/Terpenes; 0/Triterpenes; 9009-62-5/Propolis

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