| Terpenes with antimicrobial activity from Cretan propolis. | |
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MedLine Citation:
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PMID: 19698962 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Five terpenes, the diterpenes: 14,15-dinor-13-oxo-8(17)-labden-19-oic acid and a mixture of labda-8(17),13E-dien-19-carboxy-15-yl oleate and palmitate as well as the triterpenes, 3,4-seco-cycloart-12-hydroxy-4(28),24-dien-3-oic acid and cycloart-3,7-dihydroxy-24-en-28-oic acid were isolated from Cretan propolis. Moreover, 18 known compounds were also isolated, seven of them for the first time as propolis components. All structures were established on the basis of spectroscopic analysis and chemical evidence. All isolated compounds were tested for antimicrobial activity against some Gram-positive and Gram-negative bacteria as well as against some human pathogenic fungi showing a broad spectrum of antimicrobial activity. |
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Authors:
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Milena P Popova; Ioanna B Chinou; Ilko N Marekov; Vassya S Bankova |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-08-19 |
Journal Detail:
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Title: Phytochemistry Volume: 70 ISSN: 1873-3700 ISO Abbreviation: Phytochemistry Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-09-01 Completed Date: 2009-11-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0151434 Medline TA: Phytochemistry Country: United States |
Other Details:
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Languages: eng Pagination: 1262-71 Citation Subset: IM |
Affiliation:
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Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev Str. Bl. 9, 1113 Sofia, Bulgaria. popova@orgchm.bas.bg |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
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chemistry*,
pharmacology* Antifungal Agents / chemistry*, pharmacology* Candida / drug effects Diterpenes / chemistry, pharmacology Gram-Negative Bacteria / drug effects Gram-Positive Bacteria / drug effects Magnetic Resonance Spectroscopy Molecular Structure Plant Extracts / chemistry, pharmacology Propolis / chemistry* Terpenes / chemistry*, pharmacology* Triterpenes / chemistry, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Antifungal Agents; 0/Diterpenes; 0/Plant Extracts; 0/Terpenes; 0/Triterpenes; 9009-62-5/Propolis |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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