Document Detail


Terodiline inhibition of human bladder contraction. Effects in vitro and in women with unstable bladder.
MedLine Citation:
PMID:  7386219     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Terodiline, a drug with anticholinergic and calcium antagonistic properties, effectively relaxed carbachol-contracted, isolated human bladder preparations. In the concentrations used, terodiline displaced to the right the concentration-response curve obtained on cumulative addition of carbachol. The maximum response was slightly reduced only at the highest terodiline concentration used (5 microM), suggesting a mainly competitive antimuscarinic effect. Nine patients, aged 12--78 years, suffering from urge urinary incontinence were investigated by simultaneous urethro-cystometry before and after treatment with terodiline 12.5 mg twice or three times daily for 10 days. The patients reported subjective improvement with almost no side effects. Objectively, the number of uninhibited bladder contractions and the amplitude of the contractions decreased. The bladder capacity was almost doubled. There were no marked effects on bladder and urethral pressures at rest, and only two of the investigated patients had slight residual urine after treatment. The results suggest that terodiline is a promising alternative to existing drugs for inhibition of undesired detrusor activity.
Authors:
T Rud; K E Andersson; N Boye; U Ulmsten
Related Documents :
3588079 - Characterization of recumbent, ambulatory, and postexercise proteinuria in the adolescent.
219419 - Comparative chemical, biological and clinical studies of 99mtc-glucoheptonate and 99mtc...
23269119 - Exercise-induced bronchoconstriction in school-age children born extremely preterm.
7770249 - Prostacyclin and thromboxane in pregnant and nonpregnant women in response to exercise.
22422799 - Impact of chronic exercise training on the blood pressure response to orthostatic stimu...
5116209 - The relative contributions of reabsorptive rate and redistributed nephron filtration ra...
18023919 - Eating less than required versus eating less than desired. the criterion problem in the...
9259809 - Cardiorespiratory drift during exercise in the horse.
6295989 - Influence of exercise intensity and duration on biochemical adaptations in skeletal mus...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta pharmacologica et toxicologica     Volume:  46 Suppl 1     ISSN:  0001-6683     ISO Abbreviation:  Acta Pharmacol Toxicol (Copenh)     Publication Date:  1980  
Date Detail:
Created Date:  1980-08-15     Completed Date:  1980-08-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370572     Medline TA:  Acta Pharmacol Toxicol (Copenh)     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  31-8     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Butylamines / pharmacology*,  therapeutic use
Carbachol / pharmacology
Child
Child, Preschool
Dose-Response Relationship, Drug
Female
Humans
Infant
Male
Middle Aged
Muscle, Smooth / drug effects,  innervation
Parasympatholytics*
Pressure
Urethra / drug effects,  physiopathology
Urinary Bladder / drug effects,  physiopathology
Urinary Incontinence / drug therapy*
Urodynamics / drug effects
Chemical
Reg. No./Substance:
0/Butylamines; 0/Parasympatholytics; 15793-40-5/terodiline; 51-83-2/Carbachol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Anticholinergic and calcium antagonistic effects of terodiline in rabbit urinary bladder.
Next Document:  Hazards of therapy for excessive hypertension in acute stroke.