Document Detail


Termination of antigen-specific immunity by CD95 ligand (Fas ligand) and IL-10.
MedLine Citation:
PMID:  15265879     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Following elimination of a foreign invader, the immune system must return to its normal quiescent levels. This process requires removal of reactive immune cells when they are no longer needed. We have explored the role of Fas/Fas ligand (FasL) in terminating immunity and demonstrate that mice defective in these proteins have prolonged immune responses. Studies demonstrate that termination of immunity occurs via the interaction of Fas(+) lymphoid cells with FasL(+) nonlymphoid cells at the site of Ag challenge. Our results also show that FasL is absent in quiescent tissue but is rapidly up-regulated during the local immune reaction. This occurs through the production of IL-10. Thus, FasL and IL-10 work in concert to eliminate inflammatory cells and control the duration of an immune response.
Authors:
Ramon Barreiro; Gary Luker; John Herndon; Thomas A Ferguson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  173     ISSN:  0022-1767     ISO Abbreviation:  J. Immunol.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-07-21     Completed Date:  2004-11-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1519-25     Citation Subset:  AIM; IM    
Affiliation:
Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA.
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MeSH Terms
Descriptor/Qualifier:
Adoptive Transfer
Animals
Antigens / immunology
Antigens, CD95 / genetics,  physiology
Apoptosis / immunology*
Fas Ligand Protein
Immunity, Cellular
Interleukin-10 / biosynthesis,  deficiency,  physiology*
Lymphoid Tissue / immunology,  metabolism
Membrane Glycoproteins / deficiency,  physiology*
Mice
Mice, Inbred BALB C
Mice, Mutant Strains
Models, Immunological
Picryl Chloride / immunology
T-Lymphocytes / immunology,  transplantation
Grant Support
ID/Acronym/Agency:
EY02687/EY/NEI NIH HHS; EY06765/EY/NEI NIH HHS; EY12826/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Antigens; 0/Antigens, CD95; 0/Fas Ligand Protein; 0/Fasl protein, mouse; 0/Membrane Glycoproteins; 130068-27-8/Interleukin-10; 88-88-0/Picryl Chloride

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