Document Detail

Terminals of reserpine-sensitive vasopressin-neurophysin neurons in the external layer of the rat median eminence.
MedLine Citation:
PMID:  7011784     Owner:  NLM     Status:  MEDLINE    
The indirect immunofluorescence technique was used to examine the pharmacology associated with reserpine-induced alterations in vasopressin and neurophysin (VP/NP) immunoreactivity in the external layer of the median eminence in the rat. Twenty-four hours after injection of reserpine, a selective, marked depletion of VP/NP immunoreactivity from the external layer is apparent. Pretreatment with the monoamine oxidase inhibitors, pargyline and tranylcypromine, prevents the depleting effect of reserpine, indicating that the acute effect of reserpine is mediated by monoamines. Acute intraventricular treatment with 6-hydroxydopamine, but not 5,7-dihydroxytryptamine, mimicked the reserpine effect, suggesting that catecholamines mediate reserpine depletion of VP/NP immunoreactivity from the external layer. The experimental results are consistent with a regulatory model in which catecholamines tonically inhibit VP/NP release from terminals in the external layer of the median eminence. Although the studies do not definitively determine the functional relationship between VP and ACTH, the anatomical location of these terminals, the dramatic change in the VP/NP content of these terminals in response to reserpine, and the lack of a response to dehydration suggest that this pool of vasopressin may contribute to ACTH hypersecretion in response to reserpine.
V Seybold; R Elde; T Hökfelt
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Endocrinology     Volume:  108     ISSN:  0013-7227     ISO Abbreviation:  Endocrinology     Publication Date:  1981 May 
Date Detail:
Created Date:  1981-06-25     Completed Date:  1981-06-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1803-9     Citation Subset:  AIM; IM    
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MeSH Terms
Fluorescent Antibody Technique
Hypothalamo-Hypophyseal System / physiology*
Median Eminence / drug effects,  physiology*
Neurons / drug effects,  physiology*
Neurophysins / physiology*
Pargyline / pharmacology
Reserpine / pharmacology*
Tranylcypromine / pharmacology
Vasopressins / physiology*
Reg. No./Substance:
0/Neurophysins; 11000-17-2/Vasopressins; 155-09-9/Tranylcypromine; 50-55-5/Reserpine; 555-57-7/Pargyline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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