Document Detail

Terminal ligature of inferior thyroid artery branches during total thyroidectomy for multinodular goiter is associated with higher postoperative calcium and PTH levels.
MedLine Citation:
PMID:  20952270     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate the impact of truncal versus terminal branch ligature of the inferior thyroid artery (ITA) on postoperative calcium and PTH plasma levels in patients undergoing total thyroidectomy for multinodular goiter.
METHODS: A prospective randomized study was performed comparing a group of patients that underwent either truncal ligature of the ITA (group 1) or terminal ligature of ITA branches (group 2).
RESULTS: A series of 126 consecutive patients with non-toxic euthyroid multinodular goiter underwent total thyroidectomy. Truncal ligature of the ITA was performed in 63 patients (group 1) and terminal branch ITA ligature in 63 patients (group 2). Postoperative ionized serum calcium (mmol/L) at 24 hours was significantly lower in group 1 than in group 2 patients (1.22 ± 0.06 vs. 1.25 ± 0.05, P<0.05) and at 48 hours (1.20 ± 0.05 vs. 1.23 ± 0.05, P<0.05). Mean postoperative PTH levels (pg/mL) at 4 hours after thyroidectomy were significantly lower in group 1 than in group 2 patients (22.32 ± 11.64 vs. 25.82 ± 12.87, P=0.044). Mean hospital stay (hours) was higher in group 1 than in group 2 patients (87.47 ± 41.04 vs. 70.34 ± 24.82, P<0.05).
CONCLUSION: This study shows that terminal ligature of ITA branches during total thyroidectomy for multinodular goiter is associated with higher mean postoperative calcium and PTH levels, and shorter hospital stay. However, no significant difference in terms of permanent hypoparathyroidism was observed between the two groups.
G Cocchiara; M Cajozzo; G Amato; A Mularo; A Agrusa; G Romano
Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial     Date:  2010-10-16
Journal Detail:
Title:  Journal of visceral surgery     Volume:  147     ISSN:  1878-7886     ISO Abbreviation:  J Visc Surg     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-11-24     Completed Date:  2011-04-05     Revised Date:  2012-01-20    
Medline Journal Info:
Nlm Unique ID:  101532664     Medline TA:  J Visc Surg     Country:  France    
Other Details:
Languages:  eng     Pagination:  e329-32     Citation Subset:  IM    
Copyright Information:
Copyright © 2010. Published by Elsevier Masson SAS.
Department of general surgery, emergency surgery, and organ transplantation, University of Palermo, Palermo, Italy.
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MeSH Terms
Arteries / surgery
Calcium / blood*
Goiter / surgery*
Ligation / methods
Parathyroid Hormone / blood*
Postoperative Period
Prospective Studies
Thyroid Gland / blood supply*
Thyroidectomy / methods*
Reg. No./Substance:
0/Parathyroid Hormone; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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