Document Detail


Terminal deoxynucleotidyl transferase activity in childhood and adult acute lymphoblastic leukaemia.
MedLine Citation:
PMID:  6944315     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The measurement of terminal deoxynucleotidyl transferase (TDT) activity in leukaemic blasts of 26 cases of acute lymphoblastic leukaemia (ALL) (13 children less than 14 years, 13 adults greater than 14 years) demonstrated significantly greater activities of the enzyme on a proportion of the adults. The predominant cytological sub-type in the adult patients was L2 (FAB classification) whereas L1 cytological sub-type dominated in the childhood group. There was no relation between TDT values and FAB sub-type but the highest activities in the childhood group were seen in patients assessed at the time of relapse. We conclude that continued use of quantitative TDT estimations may provide useful information in further characterising the currently recognised cytological and immunological sub-types in ALL.
Authors:
S J Proctor; A M Dickinson; B Fail; W Walker; S Serisier
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of clinical pathology     Volume:  34     ISSN:  0021-9746     ISO Abbreviation:  J. Clin. Pathol.     Publication Date:  1981 Aug 
Date Detail:
Created Date:  1981-11-24     Completed Date:  1981-11-24     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0376601     Medline TA:  J Clin Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  892-5     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adolescent
Adult
Aged
Child
Child, Preschool
DNA Nucleotidylexotransferase / metabolism*
DNA Nucleotidyltransferases / metabolism*
Humans
Infant
Leukemia, Lymphoid / classification,  enzymology*
Middle Aged
Prognosis
Chemical
Reg. No./Substance:
EC 2.7.7.-/DNA Nucleotidyltransferases; EC 2.7.7.31/DNA Nucleotidylexotransferase
Comments/Corrections

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