Document Detail

Terminal dUTP nick end labeling (TUNEL) positive cells in the different regions of the brain in normal aging and Alzheimer patients.
MedLine Citation:
PMID:  9188038     Owner:  NLM     Status:  MEDLINE    
This study investigated terminal dUTP nick-end labeling (TUNEL)-positive cells in the frontal, occipital, and hippocampal cortices of seven normal aging and four Alzheimer's patients. Significant increase in TUNEL-positive cells was observed in the frontal and hippocampal cortices of Alzheimer's patients when compared with controls. In the hippocampal cortex, only area CA4 demonstrated a significant increase of TUNEL-positive cells. Double staining of TUNEL-positive cells for glial fibrillary acidic protein revealed that < 13% of the TUNEL-positive nuclei belonged to astrocytes. The results of this study illustrated a differential pattern of cortical degeneration between normal aging and Alzheimer patients.
W P Li; W Y Chan; H W Lai; D T Yew
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of molecular neuroscience : MN     Volume:  8     ISSN:  0895-8696     ISO Abbreviation:  J. Mol. Neurosci.     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-07-28     Completed Date:  1997-07-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9002991     Medline TA:  J Mol Neurosci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  75-82     Citation Subset:  IM    
Department of Neurology, First Military Medical University, Guangzhou, China.
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MeSH Terms
Aged, 80 and over
Aging / pathology*
Alzheimer Disease / mortality,  pathology*
Apoptosis / physiology
Astrocytes / chemistry,  cytology
Cell Nucleus / pathology
DNA Fragmentation*
Neurons / chemistry*,  cytology
Staining and Labeling
Uracil Nucleotides / analysis*
Reg. No./Substance:
0/Uracil Nucleotides; 58-85-5/Biotin

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