Document Detail

Term stillbirth caused by oral Fusobacterium nucleatum.
MedLine Citation:
PMID:  20093874     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Intrauterine infection is a recognized cause of adverse pregnancy outcome, but the source of infection is often undetermined. We report a case of stillbirth caused by Fusobacterium nucleatum that originated in the mother's mouth.
CASE: A woman with pregnancy-associated gingivitis experienced an upper respiratory tract infection at term, followed by stillbirth a few days later. F. nucleatum was isolated from the placenta and the fetus. Examination of different microbial floras from the mother identified the same clone in her subgingival plaque but not in the supragingival plaque, vagina, or rectum.
CONCLUSION: F. nucleatum may have translocated from the mother's mouth to the uterus when the immune system was weakened during the respiratory infection. This case sheds light on patient management for those with pregnancy-associated gingivitis.
Yiping W Han; Yann Fardini; Casey Chen; Karla G Iacampo; Victoria A Peraino; Jaime M Shamonki; Raymond W Redline
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  115     ISSN:  1873-233X     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-22     Completed Date:  2010-05-26     Revised Date:  2011-07-22    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  442-5     Citation Subset:  AIM; IM    
Department of Periodontics, School of Dental Medicine, Case Western Reserve University, Cleveland, Ohio 44106-4905, USA.
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MeSH Terms
Chorioamnionitis / microbiology
Focal Infection, Dental / complications,  microbiology*
Fusobacterium Infections / complications,  microbiology*
Fusobacterium nucleatum / isolation & purification*
Gingivitis / complications,  microbiology*
Polymerase Chain Reaction
Term Birth
Uterus / microbiology
Grant Support
K02 DE016102-03/DE/NIDCR NIH HHS; K02 DE016102-04/DE/NIDCR NIH HHS; KO2 DE 16102/DE/NIDCR NIH HHS; R01 DE 14924/DE/NIDCR NIH HHS; R01 DE014924-05A1/DE/NIDCR NIH HHS; R21 DE017165-02/DE/NIDCR NIH HHS; R21 DE171650/DE/NIDCR NIH HHS

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