| Terlipressin plus hydroxyethyl starch infusion: an effective treatment for hepatorenal syndrome. | |
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MedLine Citation:
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PMID: 12867805 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ornipressin is a vasopressin analogue that can cause potent splanchnic vasoconstriction. It has been shown that, in combination with albumin infusion, ornipressin is able to reverse hepatorenal syndrome. However, its clinical use is limited by possible severe ischaemic complications. In our case, a 47-year-old man received a right hemihepatectomy for cholangiocellular carcinoma. On post-operative day three, he developed hepatorenal syndrome with ascites, peripheral oedema and oliguria (250-500 ml/day). Serum creatinine was increased to 3.5 mg/dl. The patient was treated with terlipressin, another vasopressin analogue with fewer side effects than ornipressin, (1 mg every 4 h intravenously) and hydroxyethyl starch (500 ml/day). Urine output increased to 3000 ml/day, serum creatinine decreased to normal range within 4 days and ascites and oedema disappeared. We hereby report the first case of successful treatment of hepatorenal syndrome with terlipressin and hydroxyethyl starch, which appears to be a safe and effective treatment. |
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Authors:
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Fuat H Saner; Nils R Frühauf; Rafael F Schäfers; Hauke Lang; Massimo Malagó; Christoph E Broelsch |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: European journal of gastroenterology & hepatology Volume: 15 ISSN: 0954-691X ISO Abbreviation: Eur J Gastroenterol Hepatol Publication Date: 2003 Aug |
Date Detail:
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Created Date: 2003-07-17 Completed Date: 2003-09-29 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9000874 Medline TA: Eur J Gastroenterol Hepatol Country: England |
Other Details:
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Languages: eng Pagination: 925-7 Citation Subset: IM |
Affiliation:
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Klinik für Allgemein und Transplantationchirurgie, University Hospital Essen, Essen, Germany. fuat.saner@uni-essen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bile Duct Neoplasms
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complications,
surgery Bile Ducts, Intrahepatic / surgery Cholangiocarcinoma / complications, surgery Drug Therapy, Combination Hepatorenal Syndrome / drug therapy* Hetastarch / administration & dosage* Humans Infusions, Intravenous Lypressin / analogs & derivatives*, therapeutic use* Male Middle Aged Plasma Substitutes / administration & dosage* Postoperative Complications / drug therapy* Vasoconstrictor Agents |
| Chemical | |
Reg. No./Substance:
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0/Plasma Substitutes; 0/Vasoconstrictor Agents; 14636-12-5/terlipressin; 50-57-7/Lypressin; 9005-27-0/Hetastarch |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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