Document Detail


Terlipressin as rescue therapy for intractable hypotension during neonatal septic shock.
MedLine Citation:
PMID:  14987339     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To report the successful use of terlipressin in an 8-day-old infant for treatment of intractable hypotension caused by septic shock.
DESIGN: Descriptive case report.
SETTING: An 18-bed pediatric intensive care unit at a tertiary care children's hospital.
PATIENT: An 8-day-old child with intractable hypotension due to septic shock after heart surgery.
INTERVENTIONS: General supportive intensive care including mechanical ventilatory support, volume replacement, and inotropic support with dopamine 20 microg.kg(-1).min(-1), milrinone 0.75 microg.kg(-1).min(-1), and epinephrine 0.8 microg.kg(-1).min(-1).
MEASUREMENTS AND MAIN RESULTS: Terlipressin (7 microg/kg per dose twice daily) was added as rescue therapy because of profound intractable hypotension. Shortly after the beginning of treatment, blood pressure and perfusion dramatically improved.
CONCLUSIONS: There is circumstantial evidence that the administration of terlipressin caused the increase in blood pressure. We suggest that terlipressin should be considered as rescue therapy when high-dose catecholamine therapy does not result in sufficient perfusion pressure. Further investigation is needed to prove terlipressin's effectiveness and safety in infants and children.
Authors:
Ilan Matok; Leah Leibovitch; Amir Vardi; Miriam Adam; Marina Rubinshtein; Zohar Barzilay; Gideon Paret
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies     Volume:  5     ISSN:  1529-7535     ISO Abbreviation:  Pediatr Crit Care Med     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-02-27     Completed Date:  2004-08-17     Revised Date:  2014-07-28    
Medline Journal Info:
Nlm Unique ID:  100954653     Medline TA:  Pediatr Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  116-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Blood Pressure / drug effects
Catecholamines / therapeutic use
Humans
Hypotension / drug therapy*,  etiology
Infant, Newborn
Injections, Intravenous
Klebsiella Infections / complications
Lypressin / administration & dosage,  analogs & derivatives*,  therapeutic use*
Male
Shock, Septic / drug therapy*,  etiology
Vasoconstrictor Agents / administration & dosage,  therapeutic use*
Chemical
Reg. No./Substance:
0/Catecholamines; 0/Vasoconstrictor Agents; 14636-12-5/terlipressin; 50-57-7/Lypressin
Comments/Corrections
Comment In:
Pediatr Crit Care Med. 2004 Mar;5(2):188-9   [PMID:  15080105 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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