Document Detail

Terconazole and miconazole cream for treating vulvovaginal candidiasis. A comparison.
MedLine Citation:
PMID:  1941796     Owner:  NLM     Status:  MEDLINE    
In a double-blind, randomized, multicenter study, 900 patients diagnosed with vulvovaginal candidiasis received either 0.4% (307 patients) or 0.8% (299 patients) terconazole cream or 2.0% miconazole nitrate cream (294 patients). After seven days of treatment the combined microbiologic and clinical cure rates were 87.9% for the 0.4% terconazole group, 83.8% for patients treated with 0.8% terconazole and 81.3% for the 2.0% miconazole nitrate group. The microbiologic and clinical cure rates were similarly high. The 0.4% terconazole formulation consistently provided a greater degree of symptom relief and significantly fewer adverse genital-reproductive reactions as compared with 2.0% miconazole nitrate. All three preparations were well tolerated, with only minor adverse reactions; all three seem to be useful for the treatment of vulvovaginal candidiasis.
S L Corson; R R Kapikian; R Nehring
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  36     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-12-19     Completed Date:  1991-12-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  561-7     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia.
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MeSH Terms
Administration, Intravaginal
Antifungal Agents / administration & dosage,  adverse effects,  therapeutic use*
Candidiasis, Vulvovaginal / drug therapy*,  microbiology
Double-Blind Method
Miconazole / administration & dosage,  adverse effects,  therapeutic use*
Middle Aged
Triazoles / administration & dosage,  adverse effects,  therapeutic use*
Reg. No./Substance:
0/Antifungal Agents; 0/Triazoles; 22916-47-8/Miconazole; 67915-31-5/terconazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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