| Terbutaline decreases the blood flow of the pancreatic islets but does not reduce the diabetogenic action of streptozotocin in the rat. | |
| | |
MedLine Citation:
|
PMID: 2656272 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Male Sprague-Dawley rats were injected i.v. with either 0.5 ml saline or terbutaline (1 mg/kg body weight) and 5 min later the whole pancreatic blood flow (PBF) and the islet blood flow (IBF) were measured with a microsphere technique. Injection of terbutaline increased the serum insulin concentrations, but had no effect on the serum glucose concentration of the animals. The IBF was decreased by terbutaline by approximately 40%, while the PBF remained unchanged. Furthermore, the diabetogenic action of streptozotocin (SZ; 35 mg/kg bodyweight; i.v.) was not affected by the administration of terbutaline 5 min before the SZ injection. It is concluded that the beta 2-selective adrenoceptor agonist terbutaline selectively decreases the blood flow of the pancreatic islets in spite of its stimulatory effects on the release of insulin. This confirms our previous findings that the IBF and the release of insulin can be dissociated. Moreover, the hyperglycemic action of a single diabetogenic dose of SZ could not be reduced by terbutaline administration despite the reduction in the IBF. This suggests that a decrease in the islet blood flow is not sufficient to prevent the cytotoxicity of SZ. |
| | |
Authors:
|
L Jansson; D L Eizirik; S Sandler |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: European journal of pharmacology Volume: 161 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1989 Feb |
Date Detail:
|
Created Date: 1989-07-12 Completed Date: 1989-07-12 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 79-83 Citation Subset: IM |
Affiliation:
|
Department of Medical Cell Biology, Uppsala University, Sweden. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Glucose / metabolism Diabetes Mellitus, Experimental / physiopathology* Insulin / metabolism Islets of Langerhans / blood supply*, drug effects, metabolism Male Rats Rats, Inbred Strains Regional Blood Flow / drug effects Terbutaline / pharmacology* |
| Chemical | |
Reg. No./Substance:
|
0/Blood Glucose; 11061-68-0/Insulin; 23031-25-6/Terbutaline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of therapeutic concentrations of anthracyclines on monocyte phagocytosis of yeast cells.
Next Document: The effect of acute and chronic treatment with SCH 23390 on the spontaneous activity of midbrain dop...