| Terbinafine is more effective than itraconazole in treating toenail onychomycosis: results from a meta-analysis of randomized controlled trials. | |
| | |
MedLine Citation:
|
PMID: 14738099 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Toenail onychomycosis is a challenge for clinicians to treat, and this challenge is compounded by conflicting information in the medical literature concerning the efficacy of the two principal agents used in its treatment: terbinafine and itraconazole. OBJECTIVE: The purpose of this meta-analysis is to compare the efficacy of terbinafinewith that of itraconazole in the treatment of toenail onychomycosis caused by dermatophytes. METHODS: A Medline search was performed for all English language publications from 1966 to June 1999 on the use of terbinafine and itraconazole in the treatment of toenail onychomycosis. Included were randomized studies in which subjects received no less than 3 months (or cycles) and no more than 4 months (or cycles) of either terbinafine or itraconazole. Data were abstracted and statistical analyses (random effects model, fixed effects model, and Peto's method) were applied. RESULTS: Thirteen studies were included from the original literature review of 1636 total referenced reports; four studies did not fulfill our inclusion or exclusion criteria. The primary analysis of six studies directly comparing terbinafine to itraconazole resulted in an odds ratio ranging from 1.8 (95% CI = 1.8, 2.8) to 2.9 (1.9, 4.1). The secondary analysis of three studies comparing either itraconazole or terbinafine to placebo estimated an odds ratio of 1.1-1.7. The former shows that terbinafine is 80%-190% more likely to result in mycologic cure than is itraconazole; the latter demonstrates a 10%-70% greater likelihood. The difference between the relative efficacies of terbinafine and itraconazole was highly statistically significant (p < 0.0001). CONCLUSION: Meta-analysis of the published worldwide literature finds that terbinafine is significantly more effective than itraconazole at achieving mycologic cure of toenail onychomycosis. |
| | |
Authors:
|
Alexander H Krob; Alan B Fleischer; Ralph D'Agostino; Steven R Feldman |
Related Documents
:
|
20565449 - Pharmacological approaches to methamphetamine dependence: a focused review. 17483679 - Presbyphonia: a review. 15654209 - Effect of topical nasal steroid sprays on nasal mucosa and ciliary function. 8588799 - The aeromedical risk associated with asymptomatic cholelithiasis in usaf pilots and nav... 17620899 - Cosmetic and reconstructive medical tattooing. 10956379 - Scientific basis for the therapeutic use of withania somnifera (ashwagandha): a review. 22878029 - Development and content of a group-based intervention to improve medication adherence i... 22646729 - Colorectal smartphone apps: opportunities and risks. 23302149 - Assessment of otolaryngic knowledge in primary care residents. |
Publication Detail:
|
Type: Journal Article; Meta-Analysis |
Journal Detail:
|
Title: Journal of cutaneous medicine and surgery Volume: 7 ISSN: 1203-4754 ISO Abbreviation: J Cutan Med Surg Publication Date: 2003 Jul-Aug |
Date Detail:
|
Created Date: 2004-01-22 Completed Date: 2004-02-23 Revised Date: 2009-11-03 |
Medline Journal Info:
|
Nlm Unique ID: 9614685 Medline TA: J Cutan Med Surg Country: United States |
Other Details:
|
Languages: eng Pagination: 306-11 Citation Subset: IM |
Affiliation:
|
Westwood-Squibb Center for Dermatology Research, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1071, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antifungal Agents
/
therapeutic use* Arthrodermataceae Foot Dermatoses / drug therapy* Humans Itraconazole / therapeutic use* Naphthalenes / therapeutic use* Onychomycosis / drug therapy* Randomized Controlled Trials as Topic Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Antifungal Agents; 0/Naphthalenes; 84625-61-6/Itraconazole; 91161-71-6/terbinafine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Post-traumatic arteriovenous fistula presented with hypertrophic palmaris digitalis II.
Next Document: Axillary granular parakeratosis.