Document Detail

Teratological studies on collagen wound dressing (CAS) in mice.
MedLine Citation:
PMID:  7183770     Owner:  NLM     Status:  MEDLINE    
We subcutaneously injected collagen wound dressing (CAS) extracts equivalent to the area covering human body surface by 35 and 70%, respectively, into mouse dams from days 6 to 15 of pregnancy. No toxicity was observed in dams and no external, skeletal and visceral anomalies related to CAS treatment were observed in fetuses. It is, therefore, concluded that CAS extracts produces no teratogenesis after subcutaneous injection during organogenesis in mice.
U Takada; M Moriguchi; T Hata; A Yamamoto
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of toxicological sciences     Volume:  7 Suppl 2     ISSN:  0388-1350     ISO Abbreviation:  J Toxicol Sci     Publication Date:  1982 Dec 
Date Detail:
Created Date:  1983-08-11     Completed Date:  1983-08-11     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7805798     Medline TA:  J Toxicol Sci     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  57-61     Citation Subset:  IM    
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MeSH Terms
Abnormalities, Drug-Induced*
Bandages / adverse effects*
Biological Dressings / adverse effects*
Bone and Bones / abnormalities
Collagen / toxicity*
Fetus / drug effects
Mice, Inbred Strains
Reg. No./Substance:

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