Document Detail

Teratological evaluation of an injectable male antifertility agent, styrene maleic anhydride, in rats.
MedLine Citation:
PMID:  1355766     Owner:  NLM     Status:  MEDLINE    
Polymer styrene Maleic anhydride (SMA) dissolved in dimethylsulphoxide (DMSO) was injected into the lumen in each vas deferens of male rats at dose levels of 0.25 mg, 0.50 mg, 1.0 mg, 2.5 mg, and 5.0 mg, while control rats (groups 1) received 0.03 mL DMSO in each vas deferens. After 4 weeks, the lumen was flushed with 0.1 mL DMSO and the animals were left for another 6 weeks to regain fertility. These rats were mated with virgin and coeval females. No anomaly was observed which could be related to teratogenic action of the polymer in pregnant mothers or fetuses.
N Sethi; R K Srivastava; D Nath; R K Singh
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of fertility     Volume:  37     ISSN:  0020-725X     ISO Abbreviation:  Int. J. Fertil.     Publication Date:    1992 May-Jun
Date Detail:
Created Date:  1992-10-13     Completed Date:  1992-10-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0374717     Medline TA:  Int J Fertil     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  183-7     Citation Subset:  IM    
Division of Toxicology, Central Drug Research Institute, Lucknow, India.
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MeSH Terms
Abnormalities, Drug-Induced / etiology*
Body Height / drug effects
Dimethyl Sulfoxide / administration & dosage
Dose-Response Relationship, Drug
Embryonic and Fetal Development / drug effects
Evaluation Studies as Topic
Fetus / drug effects*
Maleic Anhydrides / toxicity*
Rats, Inbred Strains
Spermatozoa / drug effects
Styrenes / toxicity*
Reg. No./Substance:
0/Maleic Anhydrides; 0/Styrenes; 67-68-5/Dimethyl Sulfoxide

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