Document Detail


Teratological evaluation of an injectable male antifertility agent, styrene maleic anhydride, in rats.
MedLine Citation:
PMID:  1355766     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Polymer styrene Maleic anhydride (SMA) dissolved in dimethylsulphoxide (DMSO) was injected into the lumen in each vas deferens of male rats at dose levels of 0.25 mg, 0.50 mg, 1.0 mg, 2.5 mg, and 5.0 mg, while control rats (groups 1) received 0.03 mL DMSO in each vas deferens. After 4 weeks, the lumen was flushed with 0.1 mL DMSO and the animals were left for another 6 weeks to regain fertility. These rats were mated with virgin and coeval females. No anomaly was observed which could be related to teratogenic action of the polymer in pregnant mothers or fetuses.
Authors:
N Sethi; R K Srivastava; D Nath; R K Singh
Related Documents :
7369866 - Developmental toxicity of guthion in rats and mice.
15051036 - Effects of multiple courses of antenatal corticosteroids on regional brain and somatic ...
8212026 - Developmental toxicity of methanol in whole embryo culture: a comparative study with mo...
1724296 - Congenital hydrocephalus mimicking dandy-walker syndrome induced by 6-aminonicotinamide...
2737736 - Arteriolar changes in developing and chronic stages of two-kidney, one clip hypertension.
2160336 - Lack of inhibition of vasopressin-stimulated na+k+atpase by atrial natriuretic factor i...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of fertility     Volume:  37     ISSN:  0020-725X     ISO Abbreviation:  Int. J. Fertil.     Publication Date:    1992 May-Jun
Date Detail:
Created Date:  1992-10-13     Completed Date:  1992-10-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0374717     Medline TA:  Int J Fertil     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  183-7     Citation Subset:  IM    
Affiliation:
Division of Toxicology, Central Drug Research Institute, Lucknow, India.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Abnormalities, Drug-Induced / etiology*
Animals
Body Height / drug effects
Dimethyl Sulfoxide / administration & dosage
Dose-Response Relationship, Drug
Embryonic and Fetal Development / drug effects
Evaluation Studies as Topic
Fathers
Female
Fetus / drug effects*
Male
Maleic Anhydrides / toxicity*
Rats
Rats, Inbred Strains
Spermatozoa / drug effects
Styrenes / toxicity*
Chemical
Reg. No./Substance:
0/Maleic Anhydrides; 0/Styrenes; 67-68-5/Dimethyl Sulfoxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Reference period analysis of vaginal bleeding with triphasic oral contraceptive agents containing no...
Next Document:  Dexamethasone selectively regulates the activity of enzymatic markers of cerebral endothelial cell l...