| Teratological assessment of stobadine after single and repeated administration in mice. | |
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MedLine Citation:
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PMID: 7822685 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Teratological studies were performed with stobadine, a compound with antiarrhythmic and antihypoxic activity. Single i.v. injections of stobadine in the form of dihydrochloride (DH 1011) to ICR mice on days 3, 6, 9 or 12 of gestation at doses of 1 and 3 mg kg-1 had no teratogenic effect. Slight fetal toxicity was manifested by decreased fetal weight after treatment on days 3 and 6, increased incidence of rudimentary ribs after treatment on days 9 and 12 of gestation and non-significantly increased postimplantation loss after injection on day 6 of gestation. The effect of repeated oral administration in the form of dipalmitate salt (DP 1031) was studied in doses of 12.2, 61.0 and 122.0 mg kg-1 on days 4-16 of gestation. Oral exposure to 61.0 mg kg-1 DP 1031 resulted in significant reduction of implantations, live fetuses and litter weight, and after 122.0 mg kg-1 DP 1031 the fetal weight was significantly decreased. External and skeletal examinations of the fetuses revealed no evidence of teratogenesis. The relevance of the two routes of stobadine administration for risk involvement is discussed. |
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Authors:
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E Ujházy; M Dubovický; T Balonová; J Jansák; D Zeljenková |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of applied toxicology : JAT Volume: 14 ISSN: 0260-437X ISO Abbreviation: J Appl Toxicol Publication Date: 1994 Sep-Oct |
Date Detail:
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Created Date: 1995-02-16 Completed Date: 1995-02-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8109495 Medline TA: J Appl Toxicol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 357-63 Citation Subset: IM |
Affiliation:
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Institute of Experimental Pharmacology, SAS, Bratislava, Slovak Republic. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animals Bone and Bones / abnormalities, drug effects Carbolines / administration & dosage, toxicity* Embryonic and Fetal Development / drug effects Female Injections, Intravenous Litter Size / drug effects Maternal-Fetal Exchange / physiology Mice Mice, Inbred ICR Pregnancy Teratogens / toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Carbolines; 0/Teratogens; 17411-19-7/dicarbine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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