Document Detail


Teratologic evaluations of N,N-diethyl-m-toluamide (DEET) in rats and rabbits.
MedLine Citation:
PMID:  7958564     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The potential for DEET to produce developmental toxicity was evaluated in Charles River CD rats and New Zealand White rabbits. Rats were administered undiluted DEET by gavage on Gestational Days (gd) 6-15 at dosage levels of 0, 125, 250, and 750 mg/kg/day. Rabbits were administered undiluted DEET by gavage on gd 6-18 at dosage levels of 0, 30, 100, and 325 mg/kg/day. Group sizes were 25 females per group for rats and 16 females per group for rabbits. Control rats and rabbits were administered corn oil at the same dosage volumes administered in the high-dose DEET groups. In rats, maternal toxicity in the form of clinical signs including two deaths and depressed body weight and food consumption was observed at the high-dose level of 750 mg/kg/day. Rat fetal body weights per litter also were reduced at 750 mg/kg/day. In rabbits, maternal toxicity in the form of depressed body weight and food consumption was observed at the high-dose level of 325 mg/kg/day. No maternal toxicity was observed at the low- or mid-dose groups for rats or rabbits. With the exception of the reduced fetal weights in rats at 750 mg/kg, there was no evidence of fetal toxicity, no effects on any of the gestational parameters, nor were there any treatment-related increases in external, visceral, or skeletal variations or malformations in the offspring from the rats and rabbits from these studies.
Authors:
G P Schoenig; T L Neeper-Bradley; L C Fisher; R E Hartnagel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Fundamental and applied toxicology : official journal of the Society of Toxicology     Volume:  23     ISSN:  0272-0590     ISO Abbreviation:  Fundam Appl Toxicol     Publication Date:  1994 Jul 
Date Detail:
Created Date:  1994-12-01     Completed Date:  1994-12-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8200838     Medline TA:  Fundam Appl Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  63-9     Citation Subset:  IM    
Affiliation:
Toxicology/Regulatory Services, Inc., Charlottesville, Virginia 22903.
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MeSH Terms
Descriptor/Qualifier:
Animals
DEET / toxicity*
Embryonic and Fetal Development / drug effects
Female
Fetal Resorption / chemically induced
Pregnancy
Rabbits
Rats
Rats, Inbred Strains
Sex Ratio
Teratogens / toxicity*
Teratology / methods
Weight Gain / drug effects
Chemical
Reg. No./Substance:
0/Teratogens; 134-62-3/DEET

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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