Document Detail

Teratogenicity of patulin and patulin adducts formed with cysteine.
MedLine Citation:
PMID:  1275488     Owner:  NLM     Status:  MEDLINE    
The mean lethal dose of patulin for the chicken embryo injected in the air cell before incubation was determined to be 68.7 mug and that for the 4-day-old embryo was 2.35 mug. Both patulin (1 to 2 mug/egg) and the reaction mixture between patulin and cysteine (15 to 150 mug of patulin equivalents) were teratogenic to the chicken embryo. At least two ninhydrin-negative and four ninhydrin-positive products were formed during the latter reaction. Our explanation of the reaction mechanism remains to be elaborated.
A Ciegler; A C Beckwith; L K Jackson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Applied and environmental microbiology     Volume:  31     ISSN:  0099-2240     ISO Abbreviation:  Appl. Environ. Microbiol.     Publication Date:  1976 May 
Date Detail:
Created Date:  1976-08-02     Completed Date:  1976-08-02     Revised Date:  2010-09-07    
Medline Journal Info:
Nlm Unique ID:  7605801     Medline TA:  Appl Environ Microbiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  664-7     Citation Subset:  IM    
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MeSH Terms
Chick Embryo
Cysteine / metabolism
Lethal Dose 50
Patulin / metabolism,  toxicity*
Pyrans / toxicity*
Reg. No./Substance:
0/Pyrans; 0/Teratogens; 149-29-1/Patulin; 52-90-4/Cysteine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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