Document Detail


Teratogenic potential of phencyclidine in the mouse.
MedLine Citation:
PMID:  7394729     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pregnant CD-1 mice were given phencyclidine by gavage on days 6-15 of gestation, at dose levels of 60, 80, 100, and 120 mg/kg/day. The mice were killed on day 18 and the offspring were examined for external, visceral, and skeletal alterations. There was a significant increase in the average percent of malformed fetuses per litter only at the 120 mg/kg/day dose level (6.1% versus 1.2% for the control), a dose level which resulted in the death of 8 of 18 dams before scheduled sacrifice. At dose levels less than 120 mg/kg/day, the incidence of malformations was not significantly higher than the control value, in spite of the presence of overt maternal toxicity. Because a significant number of malformations was not seen at dose levels which were not highly toxic to the dams, it was concluded that phencyclidine was not demonstrated to be a teratogen in the mouse.
Authors:
T A Marks; W C Worthy; R E Staples
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Teratology     Volume:  21     ISSN:  0040-3709     ISO Abbreviation:  Teratology     Publication Date:  1980 Apr 
Date Detail:
Created Date:  1980-09-23     Completed Date:  1980-09-23     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0153257     Medline TA:  Teratology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  541-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Drug-Induced / epidemiology
Animals
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical
Female
Mice
Phencyclidine / pharmacology*,  toxicity
Pregnancy
Teratogens*
Chemical
Reg. No./Substance:
0/Teratogens; 77-10-1/Phencyclidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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