Document Detail

Teratogenic potential of phencyclidine in the mouse.
MedLine Citation:
PMID:  7394729     Owner:  NLM     Status:  MEDLINE    
Pregnant CD-1 mice were given phencyclidine by gavage on days 6-15 of gestation, at dose levels of 60, 80, 100, and 120 mg/kg/day. The mice were killed on day 18 and the offspring were examined for external, visceral, and skeletal alterations. There was a significant increase in the average percent of malformed fetuses per litter only at the 120 mg/kg/day dose level (6.1% versus 1.2% for the control), a dose level which resulted in the death of 8 of 18 dams before scheduled sacrifice. At dose levels less than 120 mg/kg/day, the incidence of malformations was not significantly higher than the control value, in spite of the presence of overt maternal toxicity. Because a significant number of malformations was not seen at dose levels which were not highly toxic to the dams, it was concluded that phencyclidine was not demonstrated to be a teratogen in the mouse.
T A Marks; W C Worthy; R E Staples
Related Documents :
18550329 - Reproductive toxic effects of tityus serrulatus scorpion venom in rats.
7162529 - Induction of congenital anomalies in offspring of female mice exposed to varying doses ...
6088449 - Morphine stimulates rapid, regular, deep, and sustained breathing efforts in fetal lambs.
19479239 - Prednisone reduces ketoconazole-induced skeletal defects in rat fetuses.
3132869 - Disposition of intrapartum narcotic analgesics in monkeys.
2637249 - The effects of fenitrothion emulsion (organic phosphorous pesticide) and its degraded s...
23569949 - Evaluation of antihepatotoxic potential of solanum xanthocarpum fruit extract against a...
8671319 - Ovarian activity and vaginal bleeding patterns with a desogestrel-only preparation at t...
21973199 - Long-term safety and efficacy of fenofibrate/pravastatin combination therapy in high ri...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Teratology     Volume:  21     ISSN:  0040-3709     ISO Abbreviation:  Teratology     Publication Date:  1980 Apr 
Date Detail:
Created Date:  1980-09-23     Completed Date:  1980-09-23     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0153257     Medline TA:  Teratology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  541-6     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Abnormalities, Drug-Induced / epidemiology
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical
Phencyclidine / pharmacology*,  toxicity
Reg. No./Substance:
0/Teratogens; 77-10-1/Phencyclidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Maternal hormone therapy and congenital heart disease.
Next Document:  The effect of pyrrolizidine alkaloids (Senecio vulgaris) on the liver mixed-funcion oxidase system.