Document Detail

Teratogenic effects of triethylene tetramine dihydrochloride on the mouse brain.
MedLine Citation:
PMID:  8410376     Owner:  NLM     Status:  MEDLINE    
The teratogenic effects of triethylene tetramine dihydrochloride (Trien-2HCl) on fetal mouse brain were studied on gestational day 19. Trien-2HCl was given throughout pregnancy at levels of 0 (control), 3,000, 6,000, or 12,000 mg/liter as drinking water, ad libitum. Mean litter size and live fetus per dam at birth were not significantly different among the four groups. The frequency of gross brain abnormalities in live fetus at birth such as hemorrhages, delayed ossification in cranium, hydrocephaly, exencephaly, and microcephaly increased with increasing levels of the drug. Microscopically, disorganization of neuronal cell layers, spongiform changes in white matter, and reduced myelin development were noted in the coronally sectioned cerebrum from Trien-2HCl-treated fetus. These abnormal findings increased dose-dependently in regard to the extent and severity at the levels of 6,000 and 12,000 mg/liter. No such changes were observed in the cerebrum of controls. These results suggest that microscopic changes in fetal brain caused by Trien-2HCl may be in part similar to those in brindled mutant mouse. Special attention should be paid to the developing fetal brain when Trien-2HCl is used during pregnancy.
H Tanaka; K Inomata; M Arima
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of nutritional science and vitaminology     Volume:  39     ISSN:  0301-4800     ISO Abbreviation:  J. Nutr. Sci. Vitaminol.     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-10-26     Completed Date:  1993-10-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0402640     Medline TA:  J Nutr Sci Vitaminol (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  177-88     Citation Subset:  IM    
Division of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, NCNP, Tokyo, Japan.
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MeSH Terms
Brain / abnormalities,  drug effects*
Dose-Response Relationship, Drug
Litter Size
Mice, Inbred C3H
Teratogens / toxicity*
Triethylenetetramine / toxicity*
Reg. No./Substance:
0/Teratogens; 112-24-3/Triethylenetetramine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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